Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-α production

被引：48

作者：

Takeuchi, S ^{[1
]}

Goto, T ^{[1
]}

Mikami, K ^{[1
]}

Miura, K ^{[1
]}

Ohshima, S ^{[1
]}

Yoneyama, K ^{[1
]}

Sato, M ^{[1
]}

Shibuya, T ^{[1
]}

Watanabe, D ^{[1
]}

Kataoka, E ^{[1
]}

Segawa, D ^{[1
]}

Endo, A ^{[1
]}

Sato, W ^{[1
]}

Yoshino, R ^{[1
]}

Watanabe, S ^{[1
]}

机构：

[1] Akita Univ, Sch Med, Dept Gastroenterol, Akita 0108543, Japan

来源：

HEPATOLOGY RESEARCH | 2005年 / 33卷 / 04期

关键词：

inchinko-to; genipin; tumor necrosis factor alpha; D-galactosamine; lipopolysaccharide;

D O I：

10.1016/j.hepres.2005.08.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Genipin is a metabolite derived from the herbal medicine Inchinko-to. Little is known about the mechanism of genipin action on acute liver injury through inflammatory cytokines. We examined the effects of genipin on production of TNF-alpha in vivo and in vitro. Mice were given GalN/LPS with or without genipin treatment. All mice not given genipin died within 12 h. But in mice given genipin, 8 of 15 mice survived for 24 h after GalN/LPS administration. Histologically, hepatic necrosis and inflammatory cells infiltration were significantly slight in mice given genipin. Serum AST and ALT activity were significantly lower in mice given genipin. Serum and liver homogenate TNF-a levels were significantly lower in mice given genipin. However, in IL-6 and IL-I beta, there were no significant differences in mice given and not given genipin. TNF-alpha, NF-kappa B activation and TNF-alpha mRNA expression in a cultured mouse macrophage-like cell line J774.1 were significantly suppressed by genipin administration. In conclusion, the present findings suggest that genipin, a metabolite derived form the herbal medicine Inchinko-to improved acute liver dysfunction by suppressive effect of TNF-alpha production. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：298 / 305

页数：8

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