Cytokines, chemokines and growth factors in wound healing

被引：320

作者：

Behm, B. ^{[1
]}

Babilas, P. ^{[1
]}

Landthaler, M. ^{[1
]}

Schreml, S. ^{[1
]}

机构：

[1] Univ Hosp Regensburg, Dept Dermatol, Regensburg, Germany

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2012年 / 26卷 / 07期

关键词：

INTERCELLULAR-ADHESION MOLECULE-1; GRANULATION-TISSUE FORMATION; KAPPA-B ACTIVATION; TGF-BETA; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; CONNEXIN EXPRESSION; SKIN MORPHOGENESIS; SIGNALING PATHWAY; SONIC HEDGEHOG;

D O I：

10.1111/j.1468-3083.2011.04415.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In wound healing, a variety of mediators have been identified throughout the years. The mediators discussed here comprise growth factors, cytokines and chemokines. These mediators act via multiple (specific) receptors to facilitate wound closure. As research in the last years has led to many new findings, there is a need to give an overview on what is known, and on what might possibly play a role as a molecular target for future wound therapy. This review aims to keep the reader up to date with selected important and novel findings regarding growth factors, cytokines and chemokines in wound healing.

引用

页码：812 / 820

页数：9

共 83 条

[1]

Amendt C, 2002, J CELL SCI, V115, P2189

[2] Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair [J].

Antsiferova, Maria ;

Klatte, Jennifer E. ;

Bodo, Enikoe ;

Paus, Ralf ;

Jorcano, Jose L. ;

Matzuk, Martin M. ;

Werner, Sabine ;

Koegel, Heidi .

LABORATORY INVESTIGATION, 2009, 89 (02) :131-141

[3] Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling [J].

Asai, Jun ;

Takenaka, Hideya ;

Kusano, Kengo F. ;

Ii, Masaaki ;

Luedemann, Corinne ;

Curry, Cynthia ;

Eaton, Elizabeth ;

Iwakura, Atsushi ;

Tsutsumi, Yoshiaki ;

Hamada, Hiromichi ;

Kishimoto, Saburo ;

Thorne, Tina ;

Kishore, Raj ;

Losordo, Douglas W. .

CIRCULATION, 2006, 113 (20) :2413-2424

[4] Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response [J].

Ashcroft, GS ;

Yang, X ;

Glick, AB ;

Weinstein, M ;

Letterio, JJ ;

Mizel, DE ;

Anzano, M ;

Greenwell-Wild, T ;

Wahl, SM ;

Deng, CX ;

Roberts, AB .

NATURE CELL BIOLOGY, 1999, 1 (05) :260-266

[5] Growth factors and cytokines in wound healing [J].

Barrientos, Stephan ;

Stojadinovic, Olivera ;

Golinko, Michael S. ;

Brem, Harold ;

Tomic-Canic, Marjana .

WOUND REPAIR AND REGENERATION, 2008, 16 (05) :585-601

[6] Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin cancer [J].

Beyer, T. A. ;

Keller, U. auf dem ;

Braun, S. ;

Schaefer, M. ;

Werner, S. .

CELL DEATH AND DIFFERENTIATION, 2007, 14 (07) :1250-1254

[7] The burden of skin diseases: 2004 - A joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology [J].

Bickers, David R. ;

Lim, Henry W. ;

Margolis, David ;

Weinstock, Martin A. ;

Goodman, Clifford ;

Faulkner, Eric ;

Gould, Ciara ;

Gemmen, Eric ;

Dall, Tim .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 55 (03) :490-500

[8] Biological roles of fibroblast growth factor-2 [J].

Bikfalvi, A ;

Klein, S ;

Pintucci, G ;

Rifkin, DB .

ENDOCRINE REVIEWS, 1997, 18 (01) :26-45

[9] IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes [J].

Boniface, K ;

Bernard, FX ;

Garcia, M ;

Gurney, AL ;

Lecron, JC ;

Morel, F .

JOURNAL OF IMMUNOLOGY, 2005, 174 (06) :3695-3702

[10] Fibroblast growth factors in epithelial repair and cytoprotection [J].

Braun, S ;

Keller, UAD ;

Steiling, H ;

Werner, S .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2004, 359 (1445) :753-757

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