Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis

被引：0
作者：
Murakami, Hiroyuki [1 ,2 ]
Makita, Masanori [1 ]
Ishikawa, Tatsunori [1 ]
Yoshioka, Takanori [1 ]
Nagakita, Keina [3 ]
Shinno, Yoko [3 ]
Yoshino, Tadashi [4 ]
Maeda, Yoshinobu [2 ]
Sunami, Kazutaka [1 ]
机构：
[1] Natl Hosp Org Okayama Med Ctr, Dept Hematol, Okayama, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol, Okayama, Japan
[3] Natl Hosp Org Okayama Med Ctr, Dept Pathol, Okayama, Japan
[4] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol, Grad Sch Med, Okayama, Japan
来源：
INTERNAL MEDICINE | 2022年 / 61卷 / 17期
关键词：
methotrexate; angioimmunoblastic T-cell lymphoma; MTX-associated lymphoproliferative disorder; plasmacytosis; RHEUMATOID-ARTHRITIS;
D O I：
10.2169/internalmedicine.8422-21
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.
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收藏
页码：2655 / 2660
页数：6
相关论文
共 18 条
  • [1] The aggressive peripheral T-cell lymphomas: 2012 Update on diagnosis, risk stratification, and management
    Armitage, James O.
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 (05) : 512 - 519
  • [2] Angioimmunoblastic T-cell lymphoma
    Dogan, A
    Attygalle, AD
    Kyriakou, C
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2003, 121 (05) : 681 - 691
  • [3] Expression of CXCL13 by neoplastic cells in angioimmunoblastic T-cell lymphoma (AITL) - A new diagnostic marker providing evidence that AITL derives from follicular helper T cells
    Dupuis, J
    Boye, K
    Martin, N
    Copie-Bergman, C
    Plonquet, A
    Fabiani, B
    Baglin, AC
    Haioun, C
    Delfau-Larue, MH
    Gaulard, P
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2006, 30 (04) : 490 - 494
  • [4] Gaulard P, 2017, WHO CLASSIFICATION T, V4th, P462
  • [5] Spectrum of bone marrow findings in patients with angioimmunoblastic T-cell lymphoma
    Grogg, Karen L.
    Morice, William G.
    Macon, William R.
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (05) : 416 - 422
  • [6] Methotrexate-associated lymphoproliferative disorders mimicking angioimmunoblastic T-cell lymphoma
    Hatanaka, Kazuhito
    Nakamura, Naoya
    Kojima, Minoru
    Ando, Kiyoshi
    Irie, Seiji
    Bunno, Maki
    Nakamine, Hirokazu
    Uekusa, Toshimasa
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2010, 206 (01) : 9 - 13
  • [7] Hoshida Y, 2007, J RHEUMATOL, V34, P322
  • [8] PATHOGENIC SIGNIFICANCE OF INTERLEUKIN-6 IN ANGIOIMMUNOBLASTIC LYMPHADENOPATHY-TYPE T-CELL LYMPHOMA
    HSU, SM
    WALDRON, JA
    FINK, L
    KING, C
    XIE, SS
    MANSOURI, A
    BARLOGIE, B
    [J]. HUMAN PATHOLOGY, 1993, 24 (02) : 126 - 131
  • [9] Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
    Iqbal, Javeed
    Weisenburger, Dennis D.
    Greiner, Timothy C.
    Vose, Julie M.
    McKeithan, Timothy
    Kucuk, Can
    Geng, Huimin
    Deffenbacher, Karen
    Smith, Lynette
    Dybkaer, Karen
    Nakamura, Shigeo
    Seto, Masao
    Delabie, Jan
    Berger, Francoise
    Loong, Florence
    Au, Wing Y.
    Ko, Young-Hyeh
    Sng, Ivy
    Armitage, James Olen
    Chan, Wing C.
    [J]. BLOOD, 2010, 115 (05) : 1026 - 1036
  • [10] Prognosis of mature T cell lymphoma is poorer than that of diffuse large B cell lymphoma in IPI low-risk group, but not in intermediate- and high-risk groups
    Kihara, Rika
    Watanabe, Tomoyuki
    Yano, Takahiro
    Uike, Naokuni
    Okamura, Seiichi
    Kawano, Fumio
    Hanada, Shuichi
    Sunami, Kazutaka
    Inoue, Nobumasa
    Sawamura, Morio
    Yoshida, Shin-ichiro
    Shimomura, Takeshi
    Kitano, Kiyoshi
    Kojima, Yuki
    Horibe, Keizo
    Nagai, Hirokazu
    [J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2013, 97 (01) : 98 - 102
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