The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?

被引:54
作者
Hermouet, Sylvie [1 ,2 ]
Vilaine, Mathias [1 ]
机构
[1] Univ Nantes, INSERM, UMR 892, Inst Rech Therapeut, Nantes, France
[2] CHU Nantes, Hematol Lab, F-44035 Nantes 01, France
来源
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2011年 / 96卷 / 11期
关键词
MYELOPROLIFERATIVE NEOPLASMS; POLYCYTHEMIA-VERA; CROHNS-DISEASE; GROWTH-FACTOR; SUSCEPTIBILITY; INTERLEUKIN-11; THROMBOSIS;
D O I
10.3324/haematol.2011.055392
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1575 / 1579
页数:6
相关论文
共 21 条
[1]   JAK2 46/1 haplotype analysis in myeloproliferative neoplasms and acute myeloid leukemia [J].
Andrikovics, H. ;
Nahajevszky, S. ;
Koszarska, M. ;
Meggyesi, N. ;
Bors, A. ;
Halm, G. ;
Lueff, S. ;
Lovas, N. ;
Matrai, Z. ;
Csomor, J. ;
Rasonyi, R. ;
Egyed, M. ;
Varkonyi, J. ;
Mikala, G. ;
Sipos, A. ;
Kozma, A. ;
Adam, E. ;
Fekete, S. ;
Masszi, T. ;
Tordai, A. .
LEUKEMIA, 2010, 24 (10) :1809-1813
[2]   Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3 [J].
Barbui, Tiziano ;
Carobbio, Alessandra ;
Finazzi, Guido ;
Vannucchi, Alessandro M. ;
Barosi, Giovanni ;
Antonioli, Elisabetta ;
Guglielmelli, Paola ;
Pancrazzi, Alessandro ;
Salmoiraghi, Silvia ;
Zilio, Pio ;
Ottomano, Cosimo ;
Marchioli, Roberto ;
Cuccovillo, Ivan ;
Bottazzi, Barbara ;
Mantovani, Alberto ;
Rambaldi, Alessandro .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (02) :315-318
[3]   Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].
Barrett, Jeffrey C. ;
Hansoul, Sarah ;
Nicolae, Dan L. ;
Cho, Judy H. ;
Duerr, Richard H. ;
Rioux, John D. ;
Brant, Steven R. ;
Silverberg, Mark S. ;
Taylor, Kent D. ;
Barmada, M. Michael ;
Bitton, Alain ;
Dassopoulos, Themistocles ;
Datta, Lisa Wu ;
Green, Todd ;
Griffiths, Anne M. ;
Kistner, Emily O. ;
Murtha, Michael T. ;
Regueiro, Miguel D. ;
Rotter, Jerome I. ;
Schumm, L. Philip ;
Steinhart, A. Hillary ;
Targan, Stephan R. ;
Xavier, Ramnik J. ;
Libioulle, Cecile ;
Sandor, Cynthia ;
Lathrop, Mark ;
Belaiche, Jacques ;
Dewit, Olivier ;
Gut, Ivo ;
Heath, Simon ;
Laukens, Debby ;
Mni, Myriam ;
Rutgeerts, Paul ;
Van Gossum, Andre ;
Zelenika, Diana ;
Franchimont, Denis ;
Hugot, Jean-Pierre ;
de Vos, Martine ;
Vermeire, Severine ;
Louis, Edouard ;
Cardon, Lon R. ;
Anderson, Carl A. ;
Drummond, Hazel ;
Nimmo, Elaine ;
Ahmad, Tariq ;
Prescott, Natalie J. ;
Onnie, Clive M. ;
Fisher, Sheila A. ;
Marchini, Jonathan ;
Ghori, Jilur .
NATURE GENETICS, 2008, 40 (08) :955-962
[4]   Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F [J].
Boissinot, M. ;
Cleyrat, C. ;
Vilaine, M. ;
Jacques, Y. ;
Corre, I. ;
Hermouet, S. .
ONCOGENE, 2011, 30 (08) :990-1001
[5]   Expression of early placenta insulin-like growth factor in breast cancer cells provides an autocrine loop that predominantly enhances invasiveness and motility [J].
Brandt, B ;
Kemming, D ;
Packeisen, J ;
Simon, R ;
Helms, M ;
Feldmann, U ;
Matuschek, A ;
Kersting, C ;
Hinrichs, B ;
Bidart, JM ;
Bellet, D ;
Bartkowiak, K ;
Dankbar, N ;
Dittmar, T ;
Sauter, G ;
Boecker, W ;
Buerger, H .
ENDOCRINE-RELATED CANCER, 2005, 12 (04) :823-837
[6]   JAK2 mutation and disease phenotype: a double L611V/V617F in cis mutation of JAK2 is associated with isolated erythrocytosis and increased activation of AKT and ERK1/2 rather than STAT5 [J].
Cleyrat, C. ;
Jelinek, J. ;
Girodon, F. ;
Boissinot, M. ;
Ponge, T. ;
Harousseau, J-L ;
Issa, J-P ;
Hermouet, S. .
LEUKEMIA, 2010, 24 (05) :1069-1073
[7]   Erythropoietin-independent erythroid colony formation by bone marrow progenitors exposed to interleukin-11 and interleukin-8 [J].
Corre-Buscail, I ;
Pineau, D ;
Boissinot, M ;
Hermouet, S .
EXPERIMENTAL HEMATOLOGY, 2005, 33 (11) :1299-1308
[8]   Genetic factors in chronic inflammation: Single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population [J].
Ferguson, Lynnette R. ;
Han, Dug Yeo ;
Fraser, Alan G. ;
Huebner, Claudia ;
Lam, Wen Jiun ;
Morgan, Angharad R. ;
Duan, He ;
Karunasinghe, Nishi .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2010, 690 (1-2) :108-115
[9]   The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms [J].
Jones, Amy V. ;
Campbell, Peter J. ;
Beer, Philip A. ;
Schnittger, Susanne ;
Vannucchi, Alessandro M. ;
Zoi, Katerina ;
Percy, Melanie J. ;
McMullin, Mary Frances ;
Scott, Linda M. ;
Tapper, William ;
Silver, Richard T. ;
Oscier, David ;
Harrison, Claire N. ;
Grallert, Harald ;
Kisialiou, Aliaksei ;
Strike, Paul ;
Chase, Andrew J. ;
Green, Anthony R. ;
Cross, Nicholas C. P. .
BLOOD, 2010, 115 (22) :4517-4523
[10]   JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms [J].
Jones, Amy V. ;
Chase, Andrew ;
Silver, Richard T. ;
Oscier, David ;
Zoi, Katerina ;
Wang, Y. Lynn ;
Cario, Holger ;
Pahl, Heike L. ;
Collins, Andrew ;
Reiter, Andreas ;
Grand, Francis ;
Cross, Nicholas C. P. .
NATURE GENETICS, 2009, 41 (04) :446-449