Sequential occurrence of diffuse large B-cell lymphoma and carcinoma in the nasopharynx A case report

被引：2

作者：

Hong, Yong Tae ^{[1
]}

Hong, Ki Hwan ^{[1
]}

机构：

[1] Chonbuk Natl Univ, Chonbuk Natl Univ Hosp, Inst Med Sci, Dept Otolaryngol HNS, Jeonju, South Korea

来源：

MEDICINE | 2018年 / 97卷 / 02期

关键词：

carcinoma; lymphoma; nasopharynx; HODGKIN LYMPHOMA;

D O I：

10.1097/MD.0000000000009595

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The sequential occurrence of the 2 malignancies development of nasopharyngeal carcinoma (NPC) and lymphoma is extremely rare and their coexistence raises the question of a common etiologic factor. Clinical findings/clinical concerns: A 71-year-old previously healthy man presented with diffuse large B-cell lymphoma (BCL) followed by NPC almost 2 years later with Epstein-Barr virus (EBV) positive. Diagnosis: Endoscopic examination characterized a fixed, hard and nontender mass in the nasopharynx and biopsies were done. Intervention: A patient successfully underwent chemotherapy for lymphoma and chemoradiation for carcinoma sequentially. Outcomes: He was followed up every 3 months for 1 year with endoscopic and radiological examinations. The nasopharynx mass was completely resolved after chemoradiation therapy. Conclusion: The presentation with diffuse large B-cell lymphoma (BCL) and NPC in this patient was perhaps caused by dual EBV infection or a different oncogenic mechanism.

引用

页数：4

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