Recent Advances in Experimental Allergy

被引:4
作者
Adams, Olivia Joan [1 ]
von Gunten, Stephan [1 ]
机构
[1] Univ Bern, Inst Pharmacol, Bern, Switzerland
基金
瑞士国家科学基金会;
关键词
Allergy; Immunomodulation; Inflammatory mechanisms; Atopic disorders; ARA H 2; FOOD ALLERGY; ATOPIC-DERMATITIS; AIRWAY INFLAMMATION; MURINE MODEL; MOUSE MODEL; T-CELLS; MITE; EPIDEMIOLOGY; ASTHMA;
D O I
10.1159/000494440
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Atopic disorders are on the rise and pose a great burden on society. A better understanding of the underlying mechanisms is required for the development of improved or novel therapeutic strategies. Here we aim to highlight recent advances in experimental allergy, with a particular focus on proposed treatment alternatives for airway disorders, atopic dermatitis, and food allergy. Furthermore, we discuss recent work focusing on molecular and cellular mechanisms that might offer candidates for future preventive or therapeutic intervention. (C) 2018 S. Karger AG, Basel
引用
收藏
页码:281 / 289
页数:9
相关论文
共 73 条
[51]   The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites [J].
Schneider, Christoph ;
Smith, David F. ;
Cummings, Richard D. ;
Boligan, Kayluz Frias ;
Hamilton, Robert G. ;
Bochner, Bruce S. ;
Miescher, Sylvia ;
Simon, Hans-Uwe ;
Pashov, Anastas ;
Vassilev, Tchavdar ;
von Gunten, Stephan .
SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (269)
[52]   Detection of the Peanut Allergens Ara h 2 and Ara h 6 in Human Breast Milk: Development of 2 Sensitive and Specific Sandwich ELISA Assays [J].
Schocker, Frauke ;
Scharf, Alexandra ;
Kull, Skadi ;
Jappe, Uta .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2017, 174 (01) :17-25
[53]   Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management [J].
Sicherer, Scott H. ;
Sampson, Hugh A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 141 (01) :41-58
[54]   Allergic rhinitis: Definition, epidemiology, detection, and pathophysiology, diagnosis [J].
Skoner, DR .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (01) :S2-S8
[55]   HOUSE DUST MITE EXPOSURE AS A CAUSE OF ASTHMA [J].
SPORIK, R ;
CHAPMAN, MD ;
PLATTSMILLS, TAE .
CLINICAL AND EXPERIMENTAL ALLERGY, 1992, 22 (10) :897-906
[56]   Lack of Fc Gamma Receptor IIIA Promotes Rather than Suppresses Humoral and Cellular Immune Responses after Mucosal or Parenteral Immunization with Antigen and Adjuvants [J].
Sun, J. -B. ;
Holmgren, J. ;
Cragg, M. S. ;
Xiang, Z. .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2017, 85 (04) :264-271
[57]   Characterization and immunobiology of house dust mite allergens [J].
Thomas, WR ;
Smith, WA ;
Hales, BJ ;
Mills, KL ;
O'Brien, RM .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2002, 129 (01) :1-18
[58]   Epidemiology and natural history of atopic diseases [J].
Thomsen, Simon F. .
EUROPEAN CLINICAL RESPIRATORY JOURNAL, 2015, 2 (01)
[59]   Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable [J].
Tindemans, Irma ;
Lukkes, Melanie ;
de Bruijn, Marjolein J. W. ;
Li, Bobby W. S. ;
van Nimwegen, Menno ;
Amsen, Derk ;
KleinJan, Alex ;
Hendriks, Rudi W. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (04) :1079-1089
[60]   Dietary Fructo-Oligosaccharides Attenuate Early Activation of CD4+ T Cells Which Produce both Th1 and Th2 Cytokines in the Intestinal Lymphoid Tissues of a Murine Food Allergy Model [J].
Tsuda, Masato ;
Arakawa, Haruka ;
Ishii, Narumi ;
Ubukata, Chihiro ;
Michimori, Mana ;
Noda, Masanari ;
Takahashi, Kyoko ;
Kaminogawa, Shuichi ;
Hosono, Akira .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2017, 174 (3-4) :121-132