Overview of Prostate Anatomy, Histology, and Pathology

被引：64

作者：

Lee, Christine H. ^{[2
]}

Akin-Olugbade, Oluyemi ^{[1
]}

Kirschenbaum, Alexander ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Urol, New York, NY 10075 USA

[2] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2011年 / 40卷 / 03期

关键词：

Prostate; Prostatic intraepithelial neoplasia; Adenocarcinoma; Mouse model; Androgen receptor; INTRAEPITHELIAL NEOPLASIA; TRANSGENIC MOUSE; CANCER; ADENOCARCINOMA; CARCINOMA; MODEL; PROGRESSION; EPITHELIUM; EXPRESSION; BIOPSY;

D O I：

10.1016/j.ecl.2011.05.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The human prostate is heterogeneous with regard to its embryologic origin. The two most prevalent diseases of aging males, benign prostatic hyperplasia and prostate cancer (PCa), arise from different zones within the prostate. The biology of PCa is also heterogeneous and even within a single individual there often exist prostate cancers with varying potential to progress and metastasize. Through careful study of the histology and molecular signatures of both the human and mouse-modeled disease, treatment decisions can be tailored to individual cases so as to optimize efficacy and minimize side effects from therapy.

引用

页码：565 / +

页数：13

共 28 条

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