Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease

被引：61

作者：

Aksamit, AJ

Preissner, CM

Homburger, HA

机构：

[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA

来源：

NEUROLOGY | 2001年 / 57卷 / 04期

关键词：

D O I：

10.1212/WNL.57.4.728

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.

引用

收藏

页码：728 / 730

页数：3

相关论文

共 9 条

[1] Brain magnetic resonance diffusion abnormalities in Creutzfeldt-Jakob disease [J].

Bahn, MM ;

Kido, DK ;

Lin, WL ;

Pearlman, AL .

ARCHIVES OF NEUROLOGY, 1997, 54 (11) :1411-1415

[2] 14-3-3 protein, neuron-specific enolase, and S-100 protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [J].

Beaudry, P ;

Cohen, P ;

Brandel, JP ;

Delasnerie-Lauprêtre, N ;

Richard, S ;

Launay, JM ;

Laplanche, JL .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 1999, 10 (01) :40-46

[3] CREUTZFELDT-JAKOB DISEASE - CORRELATION OF MRI AND NEUROPATHOLOGIC FINDINGS [J].

GERTZ, HJ ;

HENKES, H ;

CERVOSNAVARRO, J .

NEUROLOGY, 1988, 38 (09) :1481-1482

[4] The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies [J].

Hsich, G ;

Kinney, K ;

Gibbs, CJ ;

Lee, KH ;

Harrington, MG .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (13) :924-930

[5] CREUTZFELDT-JAKOB DISEASE - PATTERNS OF WORLDWIDE OCCURRENCE AND THE SIGNIFICANCE OF FAMILIAL AND SPORADIC CLUSTERING [J].

MASTERS, CL ;

HARRIS, JO ;

GAJDUSEK, DC ;

GIBBS, CJ ;

BERNOULLI, C ;

ASHER, DM .

ANNALS OF NEUROLOGY, 1979, 5 (02) :177-188

[6] NEURON-SPECIFIC ENOLASE AND S-100 PROTEIN-LEVELS IN CEREBROSPINAL-FLUID OF PATIENTS WITH VARIOUS NEUROLOGICAL DISEASES [J].

MOKUNO, K ;

KATO, K ;

KAWAI, K ;

MATSUOKA, Y ;

YANAGI, T ;

SOBUE, I .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1983, 60 (03) :443-451

[7] MRI OF CREUTZFELDT-JAKOB-DISEASE - ASYMMETRIC HIGH SIGNAL INTENSITY OF THE BASAL GANGLIA [J].

YOON, SS ;

CHAN, S ;

CHIN, S ;

LEE, K ;

GOODMAN, RR .

NEUROLOGY, 1995, 45 (10) :1932-1933

[8] Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid [J].

Zerr, I ;

Bodemer, M ;

Otto, A ;

Poser, S ;

Windl, O ;

Kretzschmar, HA ;

Gefeller, O ;

Weber, T .

LANCET, 1996, 348 (9031) :846-849

[9] Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease [J].

Zerr, I ;

Bodemer, M ;

Gefeller, O ;

Otto, M ;

Poser, S ;

Wiltfang, J ;

Windl, O ;

Kretzschmar, HA ;

Weber, T .

ANNALS OF NEUROLOGY, 1998, 43 (01) :32-40