Nutritional treatment of bone fracture

被引:15
作者
Cederholm, T
Hedström, M
机构
[1] Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden
[2] Karolinska Univ Hosp Huddinge, Neurotec Dept, Stockholm, Sweden
[3] Karolinska Univ Hosp Huddinge, Dept Orthoped, Stockholm, Sweden
[4] Karolinska Univ Hosp Huddinge, Surg Sci Ctr, Stockholm, Sweden
[5] Karolinska Univ Hosp Huddinge, Karolinska Inst, Stockholm, Sweden
关键词
bone mass; hip fracture; intervention; nutrition; osteoporosis;
D O I
10.1097/01.mco.0000172576.48772.a8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Osteoporosis and sarcopenia are nutrition-related risk factors for bone fracture and delayed recuperation from fracture. The purpose of this review was to summarize recent studies that evaluated the effect of the nutritional or anabolic treatment of patients with osteoeporotic, e.g. hip, fractures. Recent findings Four short-term supplementation trials reported trends for improved nutritional and functional status. A high dropout rate and low compliance contributed to negative deductions. The latest Cochrane update on hip fracture aftercare sticks to its previous conclusion that multinutrient feeds reduce the incidence of unfavourable outcomes, i.e. mortality and complications combined. Nandrolone in combination with liquid supplementation improved lean body mass, activities of daily living function and quality of life, effects reported to be partly similar for growth hormone treatment. Bone resorption decreased on 12 months' liquid supplementation in community dwelling osteoporotic individuals. A high protein intake was associated with a lower risk of hip fracture. Calcium and vitamin D supplementation remain the basic prevention for osteoporotic fractures. Summary Recent supplementation studies appeared to be underpowered or suffered logistic problems, but previous recommendations for multinutrient feeding in hip fracture aftercare remain. Supplementation trials of higher scientific quality are needed, and enteral feeding, anabolic treatment and multimodal approaches need to be evaluated further.
引用
收藏
页码:377 / 381
页数:5
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