Obesity predisposes to the risk of higher mortality in young COVID-19 patients

被引:89
作者
Zhang, Fengqin [1 ]
Xiong, Ying [2 ]
Wei, Yanqiu [1 ]
Hu, Yi [3 ]
Wang, Feng [4 ]
Li, Gang [5 ]
Liu, Kui [1 ]
Du, Ronghui [6 ]
Wang, Cong-Yi [7 ]
Zhu, Wenzhen [2 ]
机构
[1] Tongji Hosp, Dept Resp & Crit Care Med, NHC Key Lab Resp Dis, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, 1095 Jie Fang Ave, Wuhan 430030, Peoples R China
[3] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Pulm & Crit Care Med, Wuhan, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Outpatient Off, Wuhan, Peoples R China
[6] Pulm Hosp, Dept Resp & Crit Care Med, Bao Feng Rd, Wuhan, Hubei, Peoples R China
[7] Tongji Hosp, Ctr Biomed Res, NHC Key Lab Resp Dis, Tongji Hosp Res Bldg, Wuhan, Peoples R China
关键词
cardiac damage; coagulation activity; COVID-19; inflammatory responses; obesity; INFLUENZA A(H1N1) INFECTION;
D O I
10.1002/jmv.26039
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Although emerging data demonstrated mortality of young COVID-19 patients, no data have reported the risk factors of mortality for these young patients, and whether obesity is a risk for young COVID-19 patients remains unknown. We conducted a retrospective study including 13 young patients who died of COVID-19 and 40 matched survivors. Logistic regression was employed to characterize the risk factors of mortality in young obese COVID-19 patients. Most of the young deceased COVID-19 patients were mild cases at the time of admission, but the disease progressed rapidly featured by a higher severity of patchy shadows (100.00% vs 48.70%;P = .006), pleural thickening (61.50% vs 12.80%;P = .012), and mild pericardial effusion (76.90% vs 0.00%;P < .001). Most importantly, the deceased patients manifested higher body mass index (odds ratio [OR] = 1.354; 95% confidence interval [CI] = 1.075-1.704;P = .010), inflammation-related index C-reactive protein (OR = 1.014; 95% CI = 1.003-1.025;P = .014), cardiac injury biomarker hs-cTnI (OR = 1.420; 95% CI = 1.112-1.814;P = .005), and increased coagulation activity biomarker D-dimer (OR = 418.7;P = .047), as compared with that of survivors. Our data support that obesity could be a risk factor associated with high mortality in young COVID-19 patients, whereas aggravated inflammatory response, enhanced cardiac injury, and increased coagulation activity are likely to be the mechanisms contributing to the high mortality.
引用
收藏
页码:2536 / 2542
页数:7
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