Animal models for cutaneous vaccine delivery

被引：16

作者：

Hirschberg, Hoang J. H. B. ^{[1
]}

van Riet, Elly ^{[1
]}

Oosterhoff, Dinja ^{[1
]}

Bouwstra, Joke A. ^{[2
]}

Kersten, Gideon F. A. ^{[1
,2
]}

机构：

[1] Inst Translat Vaccinol, NL-3720 AL Bilthoven, Netherlands

[2] Leiden Univ, LACDR, NL-2300 RA Leiden, Netherlands

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2015年 / 71卷

关键词：

Animal models; Vaccine delivery; Skin barrier; Cutaneous; Intradermal; Topical; HUMAN STRATUM-CORNEUM; ADP-RIBOSYLATING EXOTOXINS; DIFFERENT BODY SITES; T-CELL RESPONSES; TRANSCUTANEOUS IMMUNIZATION; DENDRITIC CELLS; IMMUNE-RESPONSES; IN-VIVO; PROTECTIVE IMMUNITY; MICRONEEDLE ARRAYS;

D O I：

10.1016/j.ejps.2015.02.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Main challenges in skin vaccination are overcoming the stratum comeum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis. For this purpose many delivery techniques are being developed. In vivo immunogenicity and safety studies in animals are mandatory before moving to clinical trials. However, the results obtained in animals may or may not be predictive for humans. Knowledge about differences and similarities in skin architecture and immunology within a species and between species is crucial. In this review, we discuss variables, including skin morphology, skin barrier function, mechanical properties, site of application and immunology, which should be taken into account when designing animal studies for vaccination via the skin in order to support the translation to clinical trial outcomes. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：112 / 122

页数：11

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