Diphenyl ethers and depsidones from the endophytic fungus Aspergillus unguis BCC54176

被引：15

作者：

Sadorn, Karoon ^{[1
,2
]}

Saepua, Siriporn ^{[3
]}

Bunbamrung, Nantiya ^{[3
]}

Boonyuen, Nattawut ^{[3
,4
]}

Komwijit, Somjit ^{[3
]}

Rachtawee, Pranee ^{[3
]}

Pittayakhajonwut, Pattama ^{[3
]}

机构：

[1] King Mongkuts Inst Technol Ladkrabang, Dept Chem, Sch Sci, Chalongkrung Rd, Bangkok 10520, Thailand

[2] King Mongkuts Inst Technol Ladkrabang, Integrated Appl Chem Res Unit, Sch Sci, Chalongkrung Rd, Bangkok 10520, Thailand

[3] Natl Ctr Genet Engn & Biotechnol BIOTEC, Natl Sci & Technol Dev Agcy NSTDA, Thailand Sci Pk,Phaholyothin Rd, Khlong Luang 12120, Pathum Thani, Thailand

[4] Natl Sci & Technol Dev Agcy NSTDA, Natl Biobank Thailand NBT, Thailand Sci Pk,Phaholyothin Rd, Khlong Luang 12120, Pathum Thani, Thailand

来源：

TETRAHEDRON | 2022年 / 105卷

关键词：

Aspergillus; Diphenyl ether; Depsidone; Antibacterial activity; Anti-phytopathogenic activity; CORYNESPORA-CASSIICOLA; DERIVATIVES; INHIBITOR; PHTHALIDE;

D O I：

10.1016/j.tet.2021.132612

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new diphenyl ethers, aspergillusethers G-J (1-4), and one new depsidone, emeguisin D (7), together with eighteen known compounds have been isolated and characterized from the endophytic fungus Aspergillus unguis BCC54176. The chemical structures were established based on spectroscopic evidence in conjunction with a chemical transformation. Furthermore, the chemical structure of compound 7 was verified by single-crystal X-ray diffraction data. The isolated compounds were evaluated for biological activity. Compound 7, emeguisin C (10), and nidulin (14) showed antibacterial activity against Bacillus cereus with an equal MIC value of 1.56 mu g/mL, while emeguisin A (8), nornidulin (13), 2-chlorounguinol (16), and aspergillusidone C (21) displayed anti-phytopathogenic activity against Colletotrichum acutatum with the equal MIC value of 3.13 mu g/mL. Compound 7 was also active against Staphylococcus aureus with an MIC value of 1.56 mu g/mL. However, none of the tested compounds had cytotoxicity against cancerous (MCF-7 and NCI-H187) and non-cancerous (Vero) cells. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：12

共 35 条

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