Comparison of three different methodologies of pressure signal processing to monitor fluidized-bed dryers/granulators

被引：22

作者：

de Martin, Lilian ^{[1
]}

van den Dries, Kaspar ^{[2
]}

van Ommen, J. Ruud ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Chem Engn Prod & Proc Engn, NL-2628 BL Delft, Netherlands

[2] MSD, NL-5340 BH Oss, Netherlands

来源：

CHEMICAL ENGINEERING JOURNAL | 2011年 / 172卷 / 01期

关键词：

Process analytical technology; Pharmaceutical processes; Fluidization; Drying; Granulation; Signal analysis; MULTIRESOLUTION ANALYSIS; GRANULATION; DRYER; AGGLOMERATION; FLUCTUATIONS; DYNAMICS; MOISTURE; BUBBLE;

D O I：

10.1016/j.cej.2011.06.044

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The monitoring of the particle moisture content and the particle size has a great importance in the fluidized bed drying and granulation processes. Due to the implementation of the Process Analytical Technology initiative in the pharmaceutical industry, there is an increasing interest to apply on-line monitoring tools for process control. In this paper, we compare three different techniques of signal processing applied over pressure fluctuation measurements in order to monitor on-line the moisture of the particles in a fluidized bed dryer and the particle size in a fluidized bed granulator. These techniques are: (i) dominant frequency analysis, (ii) narrow-band standard deviation analysis and (iii) attractor comparison tool. The results show that the narrow band standard deviation method provides the best correlation between the data derived with the pressure fluctuation probe and the granule moisture content and particle size respectively. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：487 / 499

页数：13

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