Role of the Extracellular Matrix in Stem Cell Maintenance

被引：15

作者：

Pardo-Saganta, Ana ^{[1
]}

Calvo, Isabel A. ^{[2
]}

Saez, Borja ^{[2
]}

Prosper, Felipe ^{[1
,2
,3
]}

机构：

[1] Ctr Appl Med Res, Dept Regenerat Med, Pamplona 31008, Spain

[2] Ctr Appl Med Res, Hematol Oncol Dept, Pamplona 31008, Spain

[3] Clin Univ Navarra, Dept Hematol, Pamplona 31008, Spain

来源：

CURRENT STEM CELL REPORTS | 2019年 / 5卷 / 01期

关键词：

Extracellular matrix; Adult stem cells; Stem cell niche; Biomechanics; Tissue engineering; Organoids; REGULATES HEMATOPOIETIC STEM; BONE-MARROW NICHE; CONDITIONAL DELETION; PROGENITOR CELLS; ADIPOSE-TISSUE; GROWTH-FACTORS; IN-VITRO; INTEGRINS; ADHESION; MICROENVIRONMENT;

D O I：

10.1007/s40778-019-0149-9

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Purpose of Review Stem cells reside in specialized anatomical locations called niches where supportive stromal cells and the extracellular matrix (ECM) regulate their self-renewal and differentiation. This review explores the critical roles of the ECM in stem cell maintenance in tissue homeostasis, aging, and disease. Recent Findings It is well established that ECM proteins and their biomechanical properties control stem cell fate. In addition to specific molecular interactions, the ECM composition determines the topology and stiffness of the substrate, which also regulate stem cell behavior. Changes in the ECM during aging and disease can impair cell-ECM interactions and ultimately contribute to aging and disease pathogenesis. Summary A deeper understanding of the mechanisms by which the ECM regulates stem cell behavior in health, as well as during aging and in disease states, will facilitate the development of therapeutic strategies. These therapies should focus on recovering normal matrix synthesis and deposition aiming at promoting endogenous repair.

引用

页码：1 / 10

页数：10

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