CD4+ T cell depletion in an untreated HIV type1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load

被引：25

作者：

Andrade, Adriana ^{[1
]}

Bailey, Justin R. ^{[1
]}

Xu, Jie ^{[1
]}

Philp, Frances H. ^{[1
]}

Quinn, Thomas C. ^{[1
,2
]}

Williams, Thomas M. ^{[3
,4
]}

Ray, Stuart C. ^{[1
]}

Thomas, David L. ^{[1
]}

Blankson, Joel N. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] NIAID, NIH, Bethesda, MD 20892 USA

[3] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA

[4] Tricore Reference Labs, Albuquerque, NM USA

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 08期

关键词：

D O I：

10.1086/529387

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4(+) T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors.

引用

页码：E78 / E82

页数：5

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