Long-term survival rates of patients with nasopharyngeal carcinoma treated by radiochemotherapy: a retrospective cohort study

被引：6

作者：

Kazemian, Ali ^{[1
,2
]}

Ghalehtaki, Reza ^{[1
,2
]}

Farazmand, Borna ^{[1
]}

Taherioun, Maryam ^{[2
]}

Razmkhah, Mahdieh ^{[2
]}

Khalili, Nastaran ^{[3
,4
]}

Farhan, Farshid ^{[2
]}

Aghili, Mahdi ^{[1
,2
]}

Esmati, Ebrahim ^{[2
]}

机构：

[1] Univ Tehran Med Sci, Radiat Oncol Res Ctr, Canc Res Inst, Tehran, Iran

[2] Univ Tehran Med Sci, Canc Inst, Dept Radiat Oncol, Imam Khomeini Hosp Complex, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[4] Universal Sci Educ & Res Network USERN, Canc Immunol Project, Tehran, Iran

来源：

EGYPTIAN JOURNAL OF OTOLARYNGOLOGY | 2022年 / 38卷 / 01期

关键词：

Chemoradiation; Head and neck cancer; Iran; Nasopharyngeal cancer; Conformal radiotherapy; INTENSITY-MODULATED RADIOTHERAPY; CONCURRENT CHEMORADIOTHERAPY; INDUCTION CHEMOTHERAPY; MULTICENTER; OUTCOMES; PHASE-3; CANCER;

D O I：

10.1186/s43163-022-00212-2

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Nasopharyngeal cancer (NPC) is showing an increasing incidence in Iran. Radiation is the main treatment of this cancer. Use of new techniques such as intensity-modulated radiotherapy (IMRT) is on the rise. Here, we aimed to evaluate the oncological outcomes of NPC patients treated with three-dimensional conformal radiotherapy (3DCRT) for a more reliable comparison with IMRT in the future. Results: We reviewed the medical records of 106 patients with NPC treated by definitive radiotherapy from 2007 to 2016. Patients were treated with 70 Gy in 2-Gy fractions. Twenty-one patients died during the follow-up period. Twenty-nine patients suffered from locoregional or distant recurrences. Of these, 6 recurred after 2 years of treatment completion. The 2-year and 5-year overall survival rates were 81% and 76%, respectively. The 2-year and 5-year progression-free survival rates were 72% and 63%, respectively. The 5-year locoregional recurrence and distant metastasis-free survival rates were 68% and 69%, respectively. Conclusion: Due to high survival rates of NPC and the importance of receiving planned total dose of RT, the treatment-related toxicity and quality of life are critical considerations both for patients during active treatment and for survivors.

引用

页数：7

共 20 条

[1] Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized intergroup study 0099 [J].