An expedient stereocontrolled synthesis of 7-CIS-retinoids

被引：9

作者：

Alvarez, R ^{[1
]}

Domínguez, B ^{[1
]}

de Lera, AR ^{[1
]}

机构：

[1] Univ Vigo, Dept Quim Organ, Vigo 36200, Spain

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 13期

关键词：

D O I：

10.1081/SCC-100104430

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl (7Z)-retinoate 5 has been efficiently synthesized using as key step the Suzuki coupling of an in situ generated alkenylboronic acid and the geometrically homogeneous tetraenyliodide with (Z)-geometry, itself obtained by yodomethylenation according to Stork's conditions. Functional group manipulation then afforded (7Z)-retinal 7.

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收藏

页码：2083 / 2087

页数：5

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