Kanchanamycins, new polyol macrolide antibiotics produced by Streptomyces olivaceus Tu 4018 .2. Structure elucidation

被引：15

作者：

Stephan, H

Kempter, C

Metzger, JW

Jung, G

Potterat, O

Pfefferle, C

Fiedler, HP

机构：

[1] UNIV LAUSANNE,INST PHARMACOGNOSIE & PHYTOCHIM,CH-1015 LAUSANNE,SWITZERLAND

[2] UNIV TUBINGEN,INST BIOL,D-72076 TUBINGEN,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 08期

关键词：

D O I：

10.7164/antibiotics.49.765

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Kanchanamycins are a new group of polyol macrolide antibiotics isolated from Streptomyces olivaceus Tu 4018. They all share a common bicyclic carbon skeleton formed by a 36-membered lactone ring and a 6-membered hemiacetal ring. A feature unusual for that class of macrolides is the terminal urea moiety observed in kanchanamycin A. The structures of the kanchanamycins were determined by electrospray MS and modern 2D NMR techniques. Due to substantial overlap of the signals intensive use of inverse detected heteronuclear correlation experiments (HSQC, HMBC, 2D-HSQC-TOCSY) was made.

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页码：765 / 769

页数：5

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