Synthesis and antimicrobial screening of 5-arylidene-2-imino-4-thiazolidinones

被引：46
作者：
Chavan, Ameya A. [1 ]
Pai, Nandini R. [1 ]
机构：
[1] D G Ruparel Coll, Dept Organ Chem, Senapati Bapat Marg, Bombay 400016, Maharashtra, India
来源：
ARKIVOC | 2007年
关键词：
thiazolidin-4-one; 2-aminobenzothiazole; antifungal activity;
D O I：
10.3998/ark.5550190.0008.g16
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The condensation of 2-aminobenzothiazole-6-carboxylic acid (1) with chloroacetyl chloride in refluxing chloroform in the presence of anhydrous K2CO3 gives 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid (2). Compound (2) on treatment with KSCN in refluxing acetone yields 2-(2-imino-4-oxo-thiazolidin-3-yl)benzothiazole-6-carboxylic acid (3). Compound (3) on condensation with various aromatic aldehydes affords a series of 2-[5-(arylidene)-2-imino-4-oxo-thiazolidin-3-yl]benzothiazole-6-carboxylic acid (4a-h). The synthesized compounds (4a-h) are screened for their antibacterial as well as antifungal activity. All the tested compounds show slight to moderate activity against the selected microorganisms.
引用
收藏
页码：148 / 155
页数：8
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