miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis

被引：62
作者：
Chakraborty, Chiranjib [1 ]
Chin, Kok-Yong [2 ]
Das, Srijit [3 ]
机构：
[1] Galgotias Univ, Dept Bioinformat, Sch Comp & Informat Sci, Greater Noida, Uttar Pradesh, India
[2] Univ Kebangsaan Malaysia, Dept Pharmacol, Med Ctr, Kuala Lumpur 56000, Malaysia
[3] Univ Kebangsaan Malaysia, Dept Anat, Fac Med, Med Ctr, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 10期
关键词：
Migration; miRNA; Stem cell; Therapy; Tumor; HUMAN HEMATOPOIETIC-CELLS; GROWTH-FACTOR RECEPTOR; SELF-RENEWAL; GLIOBLASTOMA-MULTIFORME; COLORECTAL-CANCER; PANCREATIC-CANCER; IN-VITRO; CULTURED ASTROCYTES; MICRORNA BIOGENESIS; INSULIN-RESISTANCE;
D O I：
10.1007/s13277-016-5156-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.
引用
收藏
页码：13039 / 13048
页数：10
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