Efficient and chemoselective protection of alcohols and phenols with tert-butyldimethylchlorosilane (TBDMCS) under solvent-free conditions

被引：5

作者：

Firouzabadi, H ^{[1
]}

Etemadi, S ^{[1
]}

Karimi, B ^{[1
]}

Jarrahpour, AA ^{[1
]}

机构：

[1] Shiraz Univ, Dept Chem, Shiraz 71454, Iran

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1998年 / 143卷

关键词：

silylation; protection; protecting groups; silyl ethers; TBDMS ethers; solvent-free condition;

D O I：

10.1080/10426509808045483

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Various types of primary and secondary alcohols and phenols can be converted efficiently to their corresponding TBDMS ethers using TBDMCS/imidazole under solvent-free conditions. Elimination of DMF, accompanied with an easy non-aqueous work-up and a high rate enhancement of the reaction are worthy to be mentioned for the presented method. The reactions show absolute chemoselectivity for the protection of primary in the presence of secondary alcohols.

引用

页码：45 / 51

页数：7

共 19 条

[1] AN APPROACH TO THE SYNTHESIS OF BACTOBOLIN AND THE TOTAL SYNTHESIS OF N-ACETYLACTINOBOLAMINE - SOME REMARKABLY STABLE HEMIACETALS [J].