Structure and functions of classical cadherins

被引：99
作者：
Ivanov, DB [1 ]
Philippova, MP [1 ]
Tkachuk, VA [1 ]
机构：
[1] Minist Publ Hlth Russian Federat, Russian Cardiol Res & Prod Assoc, Inst Expt Cardiol, Mol Endocrinol Lab, Moscow 121552, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2001年 / 66卷 / 10期
关键词：
cadherins; cell-cell adhesion; morphogenesis; signaling; oncogenesis;
D O I：
10.1023/A:1012445316415
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cadherins are a family of membrane receptors that mediate calcium-dependent homophilic cell-cell adhesion. Cadherins play a key role in the regulation of organ and tissue development during embryogenesis. In adult organisms, these proteins are responsible for formation of stable cell-cell junctions and maintenance of normal tissue structure. Disruption in expression or function of cadherins may cause uncontrolled cell migration and proliferation during tumor development. This review focuses on the structure and physiological functions of classical cadherins.
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页码：1174 / 1186
页数：13
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