Clostridium difficile infection in humans and animals, differences and similarities

被引：73

作者：

Keessen, E. C. ^{[1
]}

Gaastra, W. ^{[2
]}

Lipman, L. J. A. ^{[1
]}

机构：

[1] Univ Utrecht, Inst Risk Assessment Sci, Div Publ Hlth & Food Safety, NL-3508 TD Utrecht, Netherlands

[2] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, NL-3508 TD Utrecht, Netherlands

来源：

VETERINARY MICROBIOLOGY | 2011年 / 153卷 / 3-4期

关键词：

Clostridium difficile; Pathogenesis; Clinical signs; Diagnosis; Prevalence; RETAIL GROUND MEAT; REAL-TIME PCR; TOXIN-A; HYDROGEN-PEROXIDE; NEONATAL SWINE; RISK-FACTORS; ANTIMICROBIAL SUSCEPTIBILITY; MONOCLONAL-ANTIBODIES; LABORATORY DIAGNOSIS; FATAL ENTEROCOLITIS;

D O I：

10.1016/j.vetmic.2011.03.020

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Clostridium difficile is well known as the most common cause of nosocomial infections in human patients. In recent years a change in epidemiology towards an increase in incidence and severity of disease, not only inside the hospital, but also in the community, is reported. C. difficile is increasingly recognized in veterinary medicine as well and is now considered the most important cause of neonatal diarrhea in swine in North America. Research on the presence of C difficile in production and companion animals revealed a huge overlap with strains implicated in human C difficile infection (CDI). This has lead to the concern that interspecies transmission of this bacterium occurs. In this review C. difficile infections in humans and animals are compared. The pathogenesis, clinical signs, diagnosis and prevalence of CDI are described and similarities and differences of CDI between humans and animals are discussed. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：205 / 217

页数：13

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