Dehydroepiandrosterone Sulphate: Action and Mechanism in the Brain

被引：41

作者：

Dong, Y. ^{[1
,2
]}

Zheng, P. ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, State Key Lab Med Neurobiol, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China

[2] Fudan Univ, Inst Brain Sci, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2012年 / 24卷 / 01期

关键词：

DHEAS; concentration; metabolism; presynaptic neurotransmitter release; postsynaptic receptor; brain function; LONG-TERM POTENTIATION; SPONTANEOUS GLUTAMATE RELEASE; CENTRAL-NERVOUS-SYSTEM; RAT PRELIMBIC CORTEX; SIGMA SIGMA RECEPTOR; NMDA-INDUCED PAIN; GABA-A RECEPTOR; IN-VIVO; NEUROACTIVE STEROIDS; ALZHEIMERS-DISEASE;

D O I：

10.1111/j.1365-2826.2011.02256.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dehydroepiandrosterone sulphate (DHEAS) is synthesised from dehydroepiandrosterone by the enzyme sulphotransferase. DHEAS is one of the most important neurosteroids in the brain. The concentration of DHEAS in the brain is sometimes higher than peripheral system. At the cellular level, DHEAS has been shown to modulate a variety of synaptic transmission, including cholinergic, GABAergic dopaminergic and glutamatergic synaptic transmission. In addition to the effect on the release of a number of neurotransmitters, DHEAS could also modulate the activity of postsynaptic receptors. DHEAS has been found to have multiple important effects on brain functions, such as memory enhancing, antidepressant and anxiolytic effects, and may have relationships with many brain diseases.

引用

收藏

页码：215 / 224

页数：10

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