Changes in Brain Network Efficiency and Working Memory Performance in Aging

被引：89

作者：

Stanley, Matthew L. ^{[1
]}

Simpson, Sean L. ^{[1
,2
]}

Dagenbach, Dale ^{[1
,3
]}

Lyday, Robert G. ^{[1
]}

Burdette, Jonathan H. ^{[1
,4
]}

Laurienti, Paul J. ^{[1
,4
]}

机构：

[1] Wake Forest Sch Med, Lab Complex Brain Networks, Winston Salem, NC 27157 USA

[2] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[3] Wake Forest Univ, Dept Psychol, Winston Salem, NC 27109 USA

[4] Wake Forest Sch Med, Dept Radiol, Winston Salem, NC USA

来源：

PLOS ONE | 2015年 / 10卷 / 04期

关键词：

RESTING-STATE NETWORKS; AGE-RELATED-CHANGES; MINI-MENTAL STATE; FUNCTIONAL CONNECTIVITY; DECISION-MAKING; ADULT AGE; ACCURACY; MODEL; ARCHITECTURE; ATTENTION;

D O I：

10.1371/journal.pone.0123950

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Working memory is a complex psychological construct referring to the temporary storage and active processing of information. We used functional connectivity brain network metrics quantifying local and global efficiency of information transfer for predicting individual variability in working memory performance on an n- back task in both young (n = 14) and older (n = 15) adults. Individual differences in both local and global efficiency during the working memory task were significant predictors of working memory performance in addition to age (and an interaction between age and global efficiency). Decreases in local efficiency during the working memory task were associated with better working memory performance in both age cohorts. In contrast, increases in global efficiency were associated with much better working performance for young participants; however, increases in global efficiency were associated with a slight decrease in working memory performance for older participants. Individual differences in local and global efficiency during resting-state sessions were not significant predictors of working memory performance. Significant group whole-brain functional network decreases in local efficiency also were observed during the working memory task compared to rest, whereas no significant differences were observed in network global efficiency. These results are discussed in relation to recently developed models of age-related differences in working memory.

引用

页数：17

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