Thiol Activation toward Selective Thiolation of Aromatic C-H Bond

被引：39

作者：

Wang, Jing-Hao ^{[1
,2
]}

Lei, Tao ^{[1
,2
]}

Wu, Hao-Lin ^{[1
,2
]}

Nan, Xiao-Lei ^{[1
,2
]}

Li, Xu-Bing ^{[1
,2
]}

Chen, Bin ^{[1
,2
]}

Tung, Chen-Ho ^{[1
,2
]}

Wu, Li-Zhu ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ARYL HALIDES; DIRECT SELENATION; EFFICIENT; FUNCTIONALIZATION; CATALYST; SYSTEM; ELECTROCHEMISTRY; DISELENIDES; ACID;

D O I：

10.1021/acs.orglett.0c01050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct C-S bond coupling is an attractive way to construct aryl sulfur ether, a building block for a variety of biological active molecules. Herein, we disclose an effective model for regioselective thiolation of the aromatic C-H bond by thiol activation instead of arene activation. Strikingly, this method has been applied into anisole derivatives that are not available in the arene activation approach to forge a single thioether isomer with high reactivity.

引用

收藏

页码：3804 / 3809

页数：6

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