The Influence of Collagen Network Integrity on the Accumulation of Gadolinium-Based MR Contrast Agents in Articular Cartilage

被引:8
作者
Wiener, E. [1 ]
Settles, M. [2 ]
Weirich, G. [3 ]
Schmidt, C. [1 ]
Diederichs, G. [1 ]
机构
[1] Charite, Inst Radiol, D-10117 Berlin, Germany
[2] Klinikum Rechts Der Isar, Inst Rontgendiagnost, Berlin, Germany
[3] Klinikum Rechts Der Isar, Inst Pathol & Patholog Anat, Munich, Germany
来源
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2011年 / 183卷 / 03期
关键词
cartilage; MR imaging; gadolinium; IN-VIVO ASSESSMENT; EXPERIMENTAL OSTEOARTHRITIS; GADOPENTETATE DIMEGLUMINE; HYALINE CARTILAGE; SPATIAL VARIATION; RELAXATION-TIME; TIBIAL PLATEAU; TESLA; PROTEOGLYCAN; KNEE;
D O I
10.1055/s-0029-1245739
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: Delayed gadolinium-enhanced MR imaging of cartilage is used to quantify the proteoglycan loss in early osteoarthritis. It is assumed that T1 after Gd-DTPA administration in the near equilibrium state reflects selective proteoglycan loss from cartilage. To investigate the influence of the collagen network integrity on contrast accumulation, the relaxation rates Delta R(1) and Delta R(2) were compared after Gd-DTPA administration in a well established model of osteoarthritis. Materials and Methods: Collagen or proteoglycan depletion was induced by the proteolytic enzymes papain and collagenase in healthy bovine patellar cartilage. Using a dedicated MRI sequence, T(1) and T(2) maps were simultaneously acquired before and 11 h after Gd-DTPA administration. Depth-dependent profiles of Delta R(1) and Delta R(2) were calculated in healthy, proteoglycan and collagen-depleted articular cartilage and the mean values of different cartilage layers were compared using the Mann-Whitney-U test. Results: In superficial layers (1 mm) there was no significant difference (p > 0.05) in either Delta R(1) or Delta R(2) between proteoglycan-depleted (16.6 +/- 1.2 s(-1), 15.9 +/- 1.0 s(-1)) and collagen-depleted articular cartilage (15.3 +/- 0.9 s(-1), 15.5 +/- 0.9 s(-1)). In deep layers (3 mm) both parameters were significantly higher (p = 0.005, 0.03) in proteoglycan-depleted articular cartilage (12.3 +/- 1.1 s(-1), 9.8 +/- 0.8 s(-1)) than in collagen-depleted articular cartilage (9.1 +/- 1.1 s(-1), 8.7 +/- 0.7 s(-1)). Conclusion: Both proteoglycan loss and alterations in the collagen network influence the accumulation of Gd-DTPA in articular cartilage with significant differences between superficial and deep cartilage layers.
引用
收藏
页码:226 / 232
页数:7
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