Smartphone-assisted colorimetric biosensor for on-site detection of Cr3+ ion analysis

被引：15

作者：

Zhang, Yuan ^{[1
]}

Xue, Tianxiang ^{[1
]}

Cheng, Liangfen ^{[1
]}

Wang, Jiayi ^{[1
]}

Shen, Ruitao ^{[2
]}

Zhang, Juan ^{[1
]}

机构：

[1] Shanghai Univ, Sch Life Sci, Res Ctr Mol Recognit & Biosensing, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Sch Commun & Informat Engn, Shanghai 200444, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2022年 / 1199卷

基金：

中国国家自然科学基金;

关键词：

Cr3+ ion; DNAzyme; Smartphone; RGB analysis; Biosensor; WASTE-WATER; FLUORESCENCE BIOSENSOR; HEXAVALENT CHROMIUM; GOLD NANOPARTICLES; OPTICAL BIOSENSOR; SPECTROMETRY; SPECIATION; MICRORNA; SAMPLES; CR(VI);

D O I：

10.1016/j.aca.2022.339603

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and low-cost biosensor has been established for the detection of Cr3+ ion by using the image processing function of the smartphone. In the presence of Cr3+ ion, its dependent DNAzyme can spe-cifically cleave the substrate strand, resulting in the release of ligation probe, which will trigger hyper-branched rolling circle amplification (HRCA) to produce hydrogen ions, causing the color change of the solution containing cresol red. A free APP named "Pixel Picker" has been further used to measure the RGB values. It can be well found that the R/G values correlate with Cr3+ ion concentrations with a linear detection range of 0.5 mu M-50 0 mu M and a lowest detection limit of 0.12 mu M. In addition, the proposed biosensor has been successfully applied to determine Cr3+ ions in various milks. In a word, the con-structed smartphone-assisted colorimetric biosensor has the advantages of simplicity, low cost, high specificity and anti-interference ability. (C) 2022 Elsevier B.V. All rights reserved.

引用

页数：7

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