Structure, DNA bonding, and biological activity of a novel Pb(II) complex of 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane

被引：5

作者：

Gao, E. -J. ^{[1
]}

Meng, B.

Su, J. -Q.

Peng, T. -T.

Qi, Z. -Z.

Jia, B.

Feng, Y. -H.

Zhu, M. -C.

机构：

[1] Shenyang Univ Chem Technol, Key Lab Inorgan Mol Based Chem Liaoning Prov, Shenyang, Liaoning, Peoples R China

来源：

JOURNAL OF STRUCTURAL CHEMISTRY | 2017年 / 58卷 / 08期

关键词：

Pb complex; DNA binding; biological activity; CRYSTAL-STRUCTURES; LIGAND; CYTOTOXICITY; ACID; ANTIBACTERIAL; LUMINESCENCE; MONONUCLEAR; TRINUCLEAR; BINDING; DFT;

D O I：

10.1134/S0022476617080121

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel complex [Pb(bptm)(NO3)(H2O)(2)] (bptm = 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane) is synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction. Its reactivity with calf thymus DNA and HeLa cell DNA is measured using UV absorption and fluorescence spectroscopies. Gel electrophoresis assay demonstrates the ability of the complex to cleave pBR322 plasmid DNA. Eventually, the complex can suitably dock with a special DNA.

引用

页码：1560 / 1566

页数：7

共 50 条

[41] 1,1-bis(1",2",3",4",5"-pentamethylferrocen-1′-yl)ethene
Heigl, OM
Herker, MA
Hiller, W
Köhler, FH
Schell, A
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1999, 574 (01) : 94 - 98
[42] An effective synthesis of (1De-1,2,4-triazol-3-yl)furoxans
Fershtat, Leonid L.
Epishina, Margarita A.
Ovchinnikov, Igor V.
Kachala, Vadim V.
Makhova, Nina N.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2015, 51 (08) : 754 - 759
[43] Spacer-Armed Copper(II) Complex Based on Bis(2-pyidyl-1,2,4-triazol-3-yl)butane and 1-Aminoethane-1,1-Diphosphonic Acid
Shul'gin, V. F.
Pevzner, N. S.
Kiskin, M. A.
Ugolkova, E. A.
Minin, V. V.
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY, 2019, 45 (11) : 795 - 798
[44] Synthesis, Characterization and Biological Activity Evaluation of Some 1,N-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) Alkanes
Alexa, Andreea-Anda
Bercean, Vasile-Nicolae
Boncea, Sabina Elena
Ledeti, Adriana
Badea, Valentin
Ridichie, Amalia
Motoc, Marilena
Ledeti, Ionut
APPLIED SCIENCES-BASEL, 2024, 14 (14):
[45] 2,3,4-triacetoxy-1-[5-(1,2,3,4-tetraacetoxybutyl)pyrazin-2-yl]butyl acetate
Gainsford, Graeme J.
Benjes, Paul A.
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O50 - U2944
[46] 1-(1,2,4-Triazol-3-yl)-1H-tetrazoles and their complexation with copper (II) chloride
Voitekhovich, Sergei V.
Grigoriev, Yuri, V
Lyakhov, Alexander S.
Matulis, Vadim E.
Ivashkevich, Ludmila S.
Bogomyakov, Artem S.
Lavrenova, Ludmila G.
Ivashkevich, Oleg A.
POLYHEDRON, 2020, 176 (176)
[47] Preparation and Characterization of 1-(5-Azido-1H-1,2,4-triazol-3-yl)tetrazole
Izsak, Daniel
Klapoetke, Thomas M.
CENTRAL EUROPEAN JOURNAL OF ENERGETIC MATERIALS, 2015, 12 (03): : 403 - 416
[48] Crystal structure of bis{2-hydroxy-N′-[1-(pyrazin-2-yl)ethylidene]benzohydrazidato}cadmium(II)
Yang, Ping
Xie, Xiao-Bao
Shi, Qing-Shan
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2021, 77 : 153 - +
[49] Synthesis, Crystal Structure and Antifungal Activity of a New Zn(II) Complex Based on 4-(5-(Pyridin-3-yl)-4H-1,2,4-triazol-3-yl) Benzoic Acidu
Song Huan
Wang Jia-Kai
Chen Xiao-Yan
Tian Xiao-Yan
Li Ying-Lian
Li Bing
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2021, 40 (01) : 103 - 108
[50] Heteroligand complexes of Nd(III), Yb(III), and Er(III) dibenzoyl methanates with bis(5-pyridin-2-yl-1,2,4-triazol-3-yl)methane
Gusev, A. N.
Shul'gin, V. F.
Nishchimenko, G. A.
Meshkova, S. B.
Kiriyak, A. V.
Aleksandrov, G. G.
Eremenko, I. L.
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY, 2013, 39 (06) : 432 - 436

← 1 2 3 4 5 →