Structure, DNA bonding, and biological activity of a novel Pb(II) complex of 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane

被引：5
|
作者：
Gao, E. -J. [1 ]
Meng, B.
Su, J. -Q.
Peng, T. -T.
Qi, Z. -Z.
Jia, B.
Feng, Y. -H.
Zhu, M. -C.
机构：
[1] Shenyang Univ Chem Technol, Key Lab Inorgan Mol Based Chem Liaoning Prov, Shenyang, Liaoning, Peoples R China
来源：
JOURNAL OF STRUCTURAL CHEMISTRY | 2017年 / 58卷 / 08期
关键词：
Pb complex; DNA binding; biological activity; CRYSTAL-STRUCTURES; LIGAND; CYTOTOXICITY; ACID; ANTIBACTERIAL; LUMINESCENCE; MONONUCLEAR; TRINUCLEAR; BINDING; DFT;
D O I：
10.1134/S0022476617080121
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A novel complex [Pb(bptm)(NO3)(H2O)(2)] (bptm = 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane) is synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction. Its reactivity with calf thymus DNA and HeLa cell DNA is measured using UV absorption and fluorescence spectroscopies. Gel electrophoresis assay demonstrates the ability of the complex to cleave pBR322 plasmid DNA. Eventually, the complex can suitably dock with a special DNA.
引用
收藏
页码：1560 / 1566
页数：7
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