The Tumor Microenvironment of DLBCL in the Computational Era

被引：30

作者：

Opinto, Giuseppina ^{[1
]}

Vegliante, Maria Carmela ^{[1
]}

Negri, Antonio ^{[1
]}

Skrypets, Tetiana ^{[1
,2
]}

Loseto, Giacomo ^{[1
]}

Pileri, Stefano Aldo ^{[3
]}

Guarini, Attilio ^{[1
]}

Ciavarella, Sabino ^{[1
]}

机构：

[1] Ist Tumori Giovanni Paolo II IIIRCCS, Unit Hematol & Cell Therapy, Lab Hematol Diagnost & Cell Characterizat, Bari, Italy

[2] Univ Modena & Reggio Emilia, CHIMOMO Dept, Modena, Italy

[3] European Inst Oncol IRCCS, Div Haematopathol, Milan, Italy

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

关键词：

tumor microenvironment; transcriptomics; deconvolution; prognostication; DLBCL; B-CELL LYMPHOMA; PROGNOSTIC-FACTORS; GENE-EXPRESSION; MACROPHAGES; SURVIVAL; ACTIVATION; SUBTYPES; STROMA; NODE;

D O I：

10.3389/fonc.2020.00351

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Among classical exemplifications of tumor microenvironment (TME) in lymphoma pathogenesis, the "effacement model" resembled by diffuse large B cell lymphoma (DLBCL) implies strong cell autonomous survival and paucity of non-malignant elements. Nonetheless, the magnitude of TME exploration is increasing as novel technologies allow the high-resolution discrimination of cellular and extra-cellular determinants at the functional, more than morphological, level. Results from genomic-scale studies and recent clinical trials revitalized the interest in this field, prompting the use of new tools to dissect DLBCL composition and reveal novel prognostic association. Here we revisited major controversies related to TME in DLBCL, focusing on the use of bioinformatics to mine transcriptomic data and provide new insights to be translated into the clinical setting.

引用

页数：7

共 56 条

[1] CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma [J].

Advani, Ranjana ;

Flinn, Ian ;

Popplewell, Leslie ;

Forero, Andres ;

Bartlett, Nancy L. ;

Ghosh, Nilanjan ;

Kline, Justin ;

Roschewski, Mark ;

LaCasce, Ann ;

Collins, Graham P. ;

Thu Tran ;

Lynn, Judith ;

Chen, James Y. ;

Volkmer, Jens-Peter ;

Agoram, Balaji ;

Huang, Jie ;

Majeti, Ravindra ;

Weissman, Irving L. ;

Takimoto, Chris H. ;

Chao, Mark P. ;

Smith, Sonali M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (18) :1711-1721

[2] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[3]

[Anonymous], ATLAS CLIN DISTINCT

[4]

[Anonymous], MICROENVIRONMENTAL S

[5] Nivolumab for Relapsed/Refractory Diffuse Large B-Cell Lymphoma in Patients Ineligible for or Having Failed Autologous Transplantation: A Single-Arm, Phase II Study [J].

Ansell, Stephen M. ;

Minnema, Monique C. ;

Johnson, Peter ;

Timmerman, John M. ;

Armand, Philippe ;

Shipp, Margaret A. ;

Rodig, Scott J. ;

Ligon, Azra H. ;

Roemer, Margaretha G. M. ;

Reddy, Nishitha ;

Cohen, Jonathon B. ;

Assouline, Sarit ;

Poon, Michelle ;

Sharma, Manish ;

Kato, Kazunobu ;

Samakoglu, Selda ;

Sumbul, Anne ;

Grigg, Andrew .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (06) :481-+

[6] Diffuse Large B-Cell Lymphoma Remodels the Fibroblastic Reticular Network That Acquires Aberrant Immunosuppressive Capabilities; Implications for the Regulation of Anti-Tumor Immunity in the Immuno-Oncology Era [J].

Apollonio, Benedetta ;

Jarvis, Peter ;

Phillips, Beth ;

Kuhnl, Andrea ;

Salisbury, Jon ;

Zacharioudakis, Georgios ;

Sutton, Lesley-Ann ;

Rosenquist, Richard ;

Jarrett, Ruth ;

Amini, Rose-Marie ;

Vardi, Anna ;

Ramsay, Alan G. .

BLOOD, 2018, 132

[7] The combined expression of the stromal markers fibronectin and SPARC improves the prediction of survival in diffuse large B-cell lymphoma [J].

Brandt S. ;

Montagna C. ;

Georgis A. ;

Schüffler P.J. ;

Bühler M.M. ;

Seifert B. ;

Thiesler T. ;

Curioni-Fontecedro A. ;

Hegyi I. ;

Dehler S. ;

Martin V. ;

Tinguely M. ;

Soldini D. .

Experimental Hematology & Oncology, 2 (1)

[8]

Cacciatore Matilde, 2012, Adv Hematol, V2012, P138079, DOI 10.1155/2012/138079

[9] High expression of tumor-infiltrating macrophages correlates with poor prognosis in patients with diffuse large B-cell lymphoma [J].

Cai, Qi-chun ;

Liao, Hong ;

Lin, Su-xia ;

Xia, Yi ;

Wang, Xiao-xaio ;

Gao, Yan ;

Lin, Ze-xiao ;

Lu, Jia-bin ;

Huang, Hui-qiang .

MEDICAL ONCOLOGY, 2012, 29 (04) :2317-2322

[10] The B-cell receptor in control of tumor B-cell fitness: Biology and clinical relevance [J].

Casola, Stefano ;

Perucho, Laura ;

Tripodo, Claudio ;

Sindaco, Paola ;

Ponzoni, Maurilio ;

Facchetti, Fabio .

IMMUNOLOGICAL REVIEWS, 2019, 288 (01) :198-213

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