Neurobiological perspectives on social phobia: From affiliation to zoology

被引:55
作者
Stein, MB [1 ]
机构
[1] Univ Calif San Diego, Dept Psychiat 0985, La Jolla, CA 92093 USA
关键词
serotonin; dopamine; neuropeptide; shyness; social anxiety;
D O I
10.1016/S0006-3223(98)00265-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Social phobia (or "social anxiety disorder") is a prevalent condition that has been the subject of increased scrutiny in recent years. The purpose of this paper is to review the neurobiology of social phobia. It is apparent from the extant literature that this disorder is poorly understood from a neurobiological perspective. There are nonetheless a number of clinical and preclinical observations which, at times, converge to illuminate areas worthy of further study. Included in this category are suggestive findings of central serotonergic dysregulation in social phobia, response to serotonin reuptake inhibitors in social phobia, and the role of serotonergic function in septohippocampal models of anxiety. Abnormalities in central dopaminergic function are also posited, supported to some extent by recent neuroimaging findings. There are in addition a number of animal and human behavioral models in existence that may be relevant to the study of social phobia. Included in this category are models of social dominance in wild baboons, social affiliation in the prairie vole, and behavioral inhibition to the unfamiliar in childhood. Newer technologies that are likely to play a major role in the delineation of the neural circuitry (e.g., functional magnetic resonance imaging) and heritability (e.g., molecular genetics) of social phobia are discussed. Finally, an interactive role for biology and experience in the expression of social phobia is considered. Biol Psychiatry 1998;44:1277-1285 (C) Society of Biological Psychiatry.
引用
收藏
页码:1277 / 1285
页数:9
相关论文
共 77 条
[1]  
BIEDERMAN J, 1990, ARCH GEN PSYCHIAT, V47, P21
[2]   Use of the selective serotonin reuptake inhibitor citalopram in the treatment of generalized social phobia [J].
Bouwer, C ;
Stein, DJ .
JOURNAL OF AFFECTIVE DISORDERS, 1998, 49 (01) :79-82
[3]   SOCIAL PHOBIA SUBTYPE AND AVOIDANT PERSONALITY-DISORDER - EFFECT ON SEVERITY OF SOCIAL PHOBIA, IMPAIRMENT, AND OUTCOME OF COGNITIVE-BEHAVIORAL TREATMENT [J].
BROWN, EJ ;
HEIMBERG, RG ;
JUSTER, HR .
BEHAVIOR THERAPY, 1995, 26 (03) :467-486
[4]   The 35% CO2 challenge test in patients with social phobia [J].
Caldirola, D ;
Perna, G ;
Arancio, C ;
Bertani, A ;
Bellodi, L .
PSYCHIATRY RESEARCH, 1997, 71 (01) :41-48
[5]  
DAVIDSON JRT, 1993, J CLIN PSYCHIAT, V54, P19
[6]   FEAR-POTENTIATED STARTLE - A NEURAL AND PHARMACOLOGICAL ANALYSIS [J].
DAVIS, M ;
FALLS, WA ;
CAMPEAU, S ;
KIM, M .
BEHAVIOURAL BRAIN RESEARCH, 1993, 58 (1-2) :175-198
[7]  
denBoer JA, 1997, BRIT MED J, V315, P796
[8]  
DIMSDALE JE, IN PRESS KAPLAN SADO
[9]   D2 dopamine receptors and personality traits [J].
Farde, L ;
Gustavsson, JP ;
Jonsson, E .
NATURE, 1997, 385 (6617) :590-590
[10]  
Flinn MV, 1997, AM J PHYS ANTHROPOL, V102, P33