Postoperative Treatment of Resectable Pancreatic Cancer With Positive Peritoneal Lavage Cytology: A Multicentre Retrospective Study

被引：0

作者：

Todaka, Akiko ^{[1
]}

Nara, Satoshi ^{[2
]}

Motoi, Fuyuhiko ^{[3
,4
]}

Morinaga, Soichiro ^{[5
]}

Toshiyama, Reishi ^{[6
]}

Higuchi, Ryota ^{[7
]}

Konishi, Masaru ^{[8
]}

Shirakawa, Hirofumi ^{[9
]}

Tsumura, Hidetaka ^{[10
]}

Okuyama, Hiroyuki ^{[11
]}

Nagano, Hiroaki ^{[12
]}

Shioji, Kazuhiko ^{[13
]}

Sugimachi, Keishi ^{[14
]}

Asagi, Akinori ^{[15
]}

Mizuno, Nobumasa ^{[16
]}

Furuse, Junji ^{[17
]}

机构：

[1] Shizuoka Canc Ctr, Div Gastrointestinal Oncol, 1007 Shimonagakubo, Nagaizumi, Shizuoka 4118777, Japan

[2] Natl Canc Ctr, Dept Hepatobiliary & Pancreat Surg, Tokyo, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Surg, Sendai, Miyagi, Japan

[4] Yamagata Univ, Grad Sch Med Sci, Dept Surg 1, Yamagata, Japan

[5] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa, Japan

[6] Natl Hosp Org Osaka Natl Hosp, Dept Surg, Osaka, Japan

[7] Tokyo Womens Med Univ, Inst Gastroenterol, Dept Surg, Tokyo, Japan

[8] Natl Canc Ctr Hosp East, Dept Hepatobiliary & Pancreat Surg, Chiba, Japan

[9] Tochigi Canc Ctr, Dept Hepatobiliary Pancreat Surg, Utsunomiya, Tochigi, Japan

[10] Hyogo Canc Ctr, Dept Gastroenterol Oncol, Akashi, Hyogo, Japan

[11] Kagawa Univ, Dept Clin Oncol, Takamatsu, Kagawa, Japan

[12] Yamaguchi Univ, Grad Sch Med, Dept Gastroenterol Breast & Endocrine Surg, Yamaguchi, Japan

[13] Niigata Canc Ctr Hosp, Dept Internal Med, Niigata, Japan

[14] Natl Hosp Org Kyushu Canc Ctr, Dept Hepatobiliary Pancreat Surg, Fukuoka, Japan

[15] Natl Hosp Org Shikoku Canc Ctr, Dept Gastrointestinal Med Oncol, Shikoku, Ehime, Japan

[16] Aichi Canc Ctr Hosp, Dept Gastroenterol, Nagoya, Aichi, Japan

[17] Kyorin Univ, Fac Med, Dept Med Oncol, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 02期

关键词：

Adjuvant therapy; gemcitabine; pancreatic cancer; positive peritoneal lavage cytology; postoperative chemotherapy; S-1; ADJUVANT CHEMOTHERAPY; SURGICAL COMPLICATIONS; WASHING CYTOLOGY; GEMCITABINE; CLASSIFICATION; S-1;

D O I：

10.21873/anticanres.15547

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: We aimed to evaluate pancreatic cancer (PC) with positive peritoneal lavage cytology (CY1) outcomes following a change in adjuvant therapy. Patients and Methods: The clinicopathological data of patients with pancreatic adenocarcinoma with CY1 at 14 institutions, between 2007 and 2015, were collected and analyzed. Results: Of the 124 eligible patients, 114 underwent macroscopically curative resection. Of the 114 patients, 80 (70%) did not have early recurrence and received postoperative chemotherapy that was S-1 in 43 (54%), gemcitabine in 31 (39%), and others in six (7%). The median overall survival was 21.0 months in S-1 and 19.2 in gemcitabine therapy (p=0.23), whereas the median relapse-free survival was 10.2 and 7.1 months (p=0.03), respectively. Conclusion: Following the change in adjuvant therapy, most PC patients with CY1 who underwent macroscopically curative resection received S-1; however, it was insufficient. Further development of postoperative chemotherapy is required.

引用

页码：893 / 902

页数：10

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