Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells

被引：25

作者：

Hwang, Mi-Hyun ^{[1
]}

Chang, Zhi-Qiang ^{[1
]}

Kang, Eun-Hee ^{[1
]}

Lim, Jong-Hwan ^{[2
]}

Yun, Hyo-In ^{[2
]}

Rhee, Man-Hee ^{[1
]}

Jeong, Kyu-Shik ^{[1
]}

Park, Seung-Chun ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea

[2] Chungnam Natl Univ, Coll Vet Med, Taejon 302305, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2008年 / 30卷 / 02期

关键词：

cyclooxygenase; cytokine; mycoplasma hyopneumoniae; nitrite; surfactin C;

D O I：

10.1007/s10529-007-9552-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Intact pathogenic Mycoplasma hyopneumoniae at 100 mu g protein ml(-1) induced transcription of proinflammatory cytokines such as cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-alpha, interleukin(IL)-1, IL-6 and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. After pretreatment with 50 mu g surfactin C/ml, purified from Bacillus subtilis, transcription of the COX-2, IL-1 beta, IL-6 and iNOS genes induced by M. hyopneumoniae was inhibited by 43%, 82%, 72% and 59%, respectively.

引用

页码：229 / 233

页数：5

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