Cryptosporidium chipmunk genotype I-An emerging cause of human cryptosporidiosis in Sweden

被引：20

作者：

Bujila, Ioana ^{[1
]}

Troell, Karin ^{[2
,3
]}

Fischerstrom, Karolina ^{[4
]}

Nordahl, Marie ^{[4
]}

Killander, Gustav ^{[1
]}

Hansen, Anette ^{[5
]}

Soderlund, Robert ^{[2
]}

Lebbad, Marianne ^{[1
]}

Beser, Jessica ^{[1
,6
]}

机构：

[1] Publ Hlth Agcy Sweden, Dept Microbiol, Solna, Sweden

[2] Swedish Natl Vet Inst, Dept Microbiol, Uppsala, Sweden

[3] Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden

[4] Dept Communicable Dis Control & Prevent, Stockholm, Stockholm Regio, Sweden

[5] Publ Hlth Agcy Sweden, Dept Communicable Dis Control & Hlth Protect, Solna, Sweden

[6] European Ctr Dis Prevent & Control ECDC, European Publ Hlth Microbiol Training Programme E, Solna, Sweden

来源：

INFECTION GENETICS AND EVOLUTION | 2021年 / 92卷

关键词：

Cryptosporidiosis; Zoonotic transmission; Molecular characterisation; Epidemiology; Outbreak investigation; MOLECULAR CHARACTERIZATION; PARVUM; INFECTION; SQUIRRELS; PROTOZOA; SAMPLES; CATTLE; SPP;

D O I：

10.1016/j.meegid.2021.104895

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Most cases of cryptosporidiosis in humans are caused by Cryptosporidium parvum or Cryptosporidium hominis. However, more uncommon species are increasingly being recognised to cause infection in humans. Here we report that Cryptosporidium chipmunk genotype I, which has various rodents as its natural host, is the third most common source of human cryptosporidiosis in Sweden. We also describe the first small outbreak of cryptosporidiosis caused by Cryptosporidium chipmunk genotype I and report the first case of zoonotic transmission of Cryptosporidium chipmunk genotype I from a red squirrel to a human. Cryptosporidium chipmunk genotype I was identified in 20 human cases, including 16 sporadic cases, three outbreak-related cases, and one zoonotic case, as well as in two squirrel samples. Gp60 subtyping which was successful for 19 human cases and two squirrel samples showed that all samples harboured the same subtype, XIVaA20G2T1. The work presented here suggests that red squirrel is a natural host of Cryptosporidium chipmunk genotype I and that infection with Cryptosporidium chipmunk genotype I is an emerging cause of domestic cryptosporidiosis in Sweden and a potential source of outbreaks.

引用

页数：8

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