Regulation of integrin-mediated adhesion during cell migration

被引：1

作者：

Cox, EA ^{[1
]}

Huttenlocher, A ^{[1
]}

机构：

[1] Univ Illinois, Dept Cell & Struct Biol, Chem & Life Sci Lab B107, Urbana, IL 61801 USA

来源：

MICROSCOPY RESEARCH AND TECHNIQUE | 1998年 / 43卷 / 05期

关键词：

D O I：

10.1002/(SICI)1097-0029(19981201)43:5<412::AID-JEMT7>3.0.CO;2-F

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Migrating cells form dynamic and highly regulated adhesive interactions with their environment. In particular, integrin-mediated adhesions to the extracellular matrix (ECM) play a central role in cell migration. This review focuses on recent advances in understanding the adhesive mechanisms that regulate cell detachment at the rear of migrating fibroblasts and neutrophils. The contribution of several key adhesive regulators is discussed, including myosin mediated cell contractility, tyrosine phosphorylation, rho, calcium fluxes, and calpain. A challenge for future investigation will be to determine how adhesive events are spatially and temporally coordinated to promote productive directional cell movements. (C) 1998 Wiley-Liss, Inc.

引用

页码：412 / 419

页数：8

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