Age-Related Changes in the Structure and Function of Brain Regions Involved in Pain Processing

被引：49

作者：

Farrell, Michael J. ^{[1
]}

机构：

[1] Univ Melbourne, Florey Neurosci Inst, Parkville, Vic 3010, Australia

来源：

PAIN MEDICINE | 2012年 / 13卷

基金：

英国医学研究理事会;

关键词：

Older Adults; Magnetic Resonance Imaging (MRI); CHRONIC BACK-PAIN; PERIAQUEDUCTAL GRAY; CORTICAL THICKNESS; OLDER-ADULTS; TONIC PAIN; MODULATION; RECEPTORS; EXPERIENCE; REDUCTION; RESPONSES;

D O I：

10.1111/j.1526-4637.2011.01287.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Objective. This review summarizes the scientific literature addressing the effects of aging on pain processing in the brain. Design. A literature search was undertaken using PubMed and search terms including pain, aging, and brain. Settings and Patients. Studies including healthy older people and older people with painful disorders were reviewed. Measures. Publications reporting the outcomes of neuroimaging techniques including positron emission tomography, structural and functional magnetic resonance imaging, and electroencephalography in samples incorporating older people were reviewed. Results. Age-related decreases in regional brain volume occur in structures implicated in pain processing, and are most pronounced in the prefrontal cortex and hippocampus, whereas age-related atrophy in brainstem regions involved in pain modulation is less pronounced. Functional brain imaging has revealed decreased pain activation in the putamen and insula among older people during extrinsic stimuli, but any effects of aging on the processing of clinical pain are yet to be reported. Conclusions. The network of brain regions involved in pain processing are subject to age-related changes in structure, but that the functional implications of these changes are yet to be determined.

引用

页码：S37 / S43

页数：7

共 68 条

[1] A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers:: normative data and relationship to physiological and demographic variables [J].

Adams, KH ;

Pinborg, LH ;

Svarer, C ;

Hasselbalch, SG ;

Holm, S ;

Haugbol, S ;

Madsen, K ;

Frokjær, V ;

Martiny, L ;

Paulson, OB ;

Knudsen, GM .

NEUROIMAGE, 2004, 21 (03) :1105-1113

[2] Cortical responses to thermal pain depend on stimulus size: A functional MRI study [J].

Apkarian, AV ;

Gelnar, PA ;

Krauss, BR ;

Szeverenyi, NM .

JOURNAL OF NEUROPHYSIOLOGY, 2000, 83 (05) :3113-3122

[3] Human brain mechanisms of pain perception and regulation in health and disease [J].

Apkarian, AV ;

Bushnell, MC ;

Treede, RD ;

Zubieta, JK .

EUROPEAN JOURNAL OF PAIN, 2005, 9 (04) :463-484

[4] Chronic back pain is associated with decreased prefrontal and thalamic gray matter density [J].

Apkarian, AV ;

Sosa, Y ;

Sonty, S ;

Levy, RM ;

Harden, RN ;

Parrish, TB ;

Gitelman, DR .

JOURNAL OF NEUROSCIENCE, 2004, 24 (46) :10410-10415

[5] A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis [J].

Baliki, Marwan N. ;

Geha, Paul Y. ;

Jabakhanji, Rami ;

Harden, Norm ;

Schnitzer, Thomas J. ;

Apkarian, A. Vania .

MOLECULAR PAIN, 2008, 4

[6] Imaging how attention modulates pain in humans using functional MRI [J].

Bantick, SJ ;

Wise, RG ;

Ploghaus, A ;

Clare, S ;

Smith, SM ;

Tracey, I .

BRAIN, 2002, 125 :310-319

[7] Chronic pain is associated with brain volume loss in older adults: Preliminary evidence [J].

Buckalew, Neilly ;

Haut, Marc W. ;

Morrow, Lisa ;

Weiner, Debra .

PAIN MEDICINE, 2008, 9 (02) :240-248

[8] Hemispheric asymmetry reduction in older adults: The HAROLD model [J].

Cabeza, R .

PSYCHOLOGY AND AGING, 2002, 17 (01) :85-100

[9] The effect of age on A delta- and C-fibre thermal pain perception [J].

Chakour, MC ;

Gibson, SJ ;

Bradbeer, M ;

Helme, RD .

PAIN, 1996, 64 (01) :143-152

[10] Pain intensity processing within the human brain: A bilateral, distributed mechanism [J].

Coghill, RC ;

Sang, CN ;

Maisog, JH ;

Iadarola, MJ .

JOURNAL OF NEUROPHYSIOLOGY, 1999, 82 (04) :1934-1943

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