Molecular Characterization of Malignant Mesothelioma: Time for New Targets?

被引：6

作者：

Aggarwal, Charu ^{[1
]}

Albelda, Steven M. ^{[2
]}

机构：

[1] Univ Penn, Dept Med, Perelman Sch Med, Div Hematol Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Med, Div Pulm Med, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

CANCER DISCOVERY | 2018年 / 8卷 / 12期

关键词：

MUTATIONS;

D O I：

10.1158/2159-8290.CD-18-1181

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant pleural mesothelioma (MPM) is an aggressive lethal malignancy for which very few therapeutic options exist. In this issue of Cancer Discovery, Hmeljak and colleagues report on a comprehensive integrative analysis of histology-independent genomic characteristics of MPM. They confirm previous observations that inactivation of tumor suppressor genes is the predominant oncogenic mechanism. This study provides a scientific rationale for potentially novel therapeutic options, including immune-checkpoint targeting VISTA and small-molecule inhibitors targeting the epigenome, DNA-repair pathways, and aurora kinase. (c) 2018 AACR.

引用

页码：1508 / 1510

页数：3

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