Maternal Serum S100-B, PAPP-A and IL-6 levels in severe preeclampsia

Aim We aimed to investigate the relationship of maternal serum levels of S100-B, PAPP-A and IL-6 with severe preeclampsia. Materials and methods This prospective case-control study consisted of 27 severe preeclamptic and 36 healthy singleton pregnancies. The groups were matched for parity, maternal age and body mass index. Maternal blood sampling for S100B, PAPP-A and IL-6 was performed at the morning after an overnight fasting. Results S100-B concentrations were significantly higher in severe preeclampsia group (0.09 +/- 0.05 vs. 0.13 +/- 0.01 lg/L; p = 0.025). PAPP-A levels were higher (196.54 +/- 21.56 vs. 208.80 +/- 23.97 mIU/ml; p = 0.707) and IL-6 levels were lower in severe preeclamptic group (68.79 +/- 29.89 vs. 37.30 +/- 6.46 pg/ml; p = 0.372). AUC value for S100-B was calculated as 0.712. When cutoff level for serum S100-B for predicting severe preeclampsia was regarded as 0.0975 lg/L, sensitivity and specificity were found to be 81.4 % and 58.3 %, respectively. Pregnancies with C0.0975 lg/L S100-B levels had 12.75-fold increased risk for having CNS symptoms (OR 12.75; 95 % CI 2.69-60.28) and 3.27-fold increased risk for having HELLP syndrome (OR 3.27; 95 % CI 0.62-17.36). Conclusion Our results suggest that serum S100B levels may be a potential marker in severe preeclampsia for the severity of hypoperfusion both in placenta and brain pointing at subsequent risk of organ failure.