Neuregulin-1: A potential endogenous protector in perinatal brain white matter damage

被引：26

作者：

Dammann, Olaf ^{[1
,3
,4
,5
]}

Bueter, Wolfgang ^{[2
]}

Leviton, Alan ^{[2
,3
,4
,5
]}

Gressens, Pierre ^{[6
,7
,8
]}

Dammann, Christiane E. L. ^{[1
,2
]}

机构：

[1] Tufts Univ, New England Med Ctr, Div Newborn Med, Dept Pediat, Boston, MA 02111 USA

[2] Hannover Med Sch, Dept Pediat Pulmonol & Neonatol, Perinatal ID Epidemiol Unit, D-3000 Hannover, Germany

[3] Hannover Med Sch, Dept Gynecol & Obstet, D-3000 Hannover, Germany

[4] Childrens Hosp, Dept Neurol, Neuroepidemiol Unit, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] INSERM, U676, Paris, France

[7] Univ Paris 07, Fac Med Denis Diderot, IFR02, Paris, France

[8] Univ Paris 07, Fac Med Denis Diderot, IFR25, Paris, France

来源：

NEONATOLOGY | 2008年 / 93卷 / 03期

关键词：

infant; premature; brain; white matter damage; cerebral palsy; inflammation; neuregulin; pathogenesis;

D O I：

10.1159/000111119

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Brain white matter damage, an important antecedent of long-term disabilities among preterm infants, has both endogenous and exogenous components. One of the endogenous components is the paucity of developmentally regulated protectors. Here we expand on this component, discussing the potential roles of one putative protector, neuregulin (NRG)-1, in brain development and damage. We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention. Copyright (C) 2007 S. Karger AG, Basel.

引用

页码：182 / 187

页数：6

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