Posttransplant Lymphoproliferative Disorder in Solid Organ and Hematopoietic Stem Cell Transplantation

被引：10
作者：
Nagle, Sarah J. [1 ]
Reshef, Ran [2 ,3 ]
Tsai, Donald E. [1 ]
机构：
[1] Hosp Univ Penn, Div Hematol & Oncol, Dept Med, Perelman Ctr Adv Med, West Pavil,4th Floor,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA
[2] Columbia Univ Coll Phys & Surg, Blood & Marrow Transplantat Program, New York, NY USA
[3] Columbia Univ Coll Phys & Surg, Columbia Ctr Translat Immunol, New York, NY USA
来源：
CLINICS IN CHEST MEDICINE | 2017年 / 38卷 / 04期
关键词：
Posttransplant lymphoproliferative disorder; Epstein-Barr virus; Epstein-Barr virus cytotoxic T cells; Allogeneic hematopoietic stem cell transplantation; Solid organ transplantation; EPSTEIN-BARR-VIRUS; MONOCLONAL-ANTIBODY RITUXIMAB; CYTOTOXIC T-LYMPHOCYTES; NON-HODGKIN-LYMPHOMA; ADOPTIVE IMMUNOTHERAPY; ANTIVIRAL PROPHYLAXIS; LUNG TRANSPLANTATION; LIVER-TRANSPLANT; INITIAL THERAPY; VIRAL LOAD;
D O I：
10.1016/j.ccm.2017.08.001
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Posttransplant lymphoproliferative disorders (PTLD) represent an immunosuppression-related lymphoid or plasmacytic proliferation that occurs in the setting of solid organ transplant or allogeneic hematopoietic stem cell transplantation (HSCT). PTLD is a devastating consequence of HSCT and solid organ transplantation with a high morbidity and mortality. Most commonly, PTLD is related to Epstein-Barr virus (EBV) infection, but an increasing number of non-EBV-related cases are occurring. Initial therapy involves withdrawal of immunosuppression with or without antibody or cytotoxic chemotherapy. Novel therapeutic approaches including EBV-specific cytotoxic T lymphocytes are currently being studied.
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收藏
页码：771 / +
页数：14
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