Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet

被引：36

作者：

Razquin, Cristina ^{[1
,2
,3
]}

Ruiz-Canela, Miguel ^{[1
,2
,3
]}

Toledo, Estefania ^{[1
,2
,3
]}

Hernandez-Alonso, Pablo ^{[3
,4
,5
,6
]}

Clish, Clary B. ^{[7
,8
]}

Guasch-Ferre, Marta ^{[9
,10
,11
]}

Li, Jun ^{[9
]}

Wittenbecher, Clemens ^{[9
,12
,13
]}

Dennis, Courtney ^{[7
,8
]}

Alonso-Gomez, Angel ^{[3
,14
,15
]}

Fito, Montse ^{[3
,16
]}

Liang, Liming ^{[17
,18
]}

Corella, Dolores ^{[3
,19
]}

Gomez-Gracia, Enrique ^{[3
,20
]}

Estruch, Ramon ^{[3
,21
]}

Fiol, Miquel ^{[3
,22
]}

Lapetra, Jose ^{[3
,23
]}

Serra-Majem, Lluis ^{[3
,24
]}

Ros, Emilio ^{[3
,25
]}

Aros, Fernando ^{[3
,14
,15
]}

Salas-Salvado, Jordi ^{[3
,4
,6
]}

Hu, Frank B. ^{[9
,10
,11
]}

Martinez-Gonzalez, Miguel A. ^{[1
,2
,3
,9
]}

机构：

[1] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain

[2] Navarra Hlth Res Inst IdiSNA, Pamplona, Spain

[3] Carlos III Inst Hlth, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid, Spain

[4] Rovira & Virgili Univ, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain

[5] Virgen Victoria Hosp, Malaga Biomed Res Inst IBIMA, Endocrinol & Nutr Clin Management Unit, Malaga, Spain

[6] San Joan Reus Univ Hosp, Pere Virgili Hlth Res Inst IISPV, Reus, Spain

[7] MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[8] Harvard Univ, Cambridge, MA 02138 USA

[9] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[10] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[11] Harvard Med Sch, Boston, MA 02115 USA

[12] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[13] German Ctr Diabet Res DZD, Neuherberg, Germany

[14] Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain

[15] Univ Basque Country UPV EHU, Vitoria, Spain

[16] Hosp Mar Inst Med Res IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain

[17] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[18] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

[19] Univ Valencia, Dept Prevent Med, Valencia, Spain

[20] Univ Malaga, Dept Prevent Med, Malaga, Spain

[21] Univ Barcelona, Hosp Clin, August Pi & Sunyer Biomed Res Inst IDIBAPS, Dept Internal Med, Barcelona, Spain

[22] Son Espases Univ Hosp, Balearic Isl Hlth Res Inst IdISBa, Clin Trials Platform, Palma De Mallorca, Spain

[23] Seville Primary Care Hlth Dist, Res Unit, Dept Family Med, Seville, Spain

[24] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Nutr Res Grp, Las Palmas Gran Canaria, Spain

[25] Univ Barcelona, Hosp Clin, August Pi & Sunyer Biomed Res Inst IDIBAPS, Lipid Clin,Dept Endocrinol & Nutr, Barcelona, Spain

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2021年 / 114卷 / 05期

关键词：

tryptophan; kynurenine; heart failure; atrial fibrillation; metabolomics; Mediterranean diet; case-control; PREDIMED; CARDIOVASCULAR-DISEASE; OLIVE OIL; INFLAMMATION; BIOMARKERS; PREDICTORS; CANCER; ADULTS;

D O I：

10.1093/ajcn/nqab238

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease. Objectives: We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevencion con Dieta MediterrAnea) trial with Mediterranean diet (MedDiet). Methods: Two case-control studies nested within the PREDIMED trial were designed. We selected 324 incident HF cases and 502 incident AF cases individually matched with <= 3 controls. Conditional logistic regression models were fitted. Interactions with the intervention were tested for each of the baseline plasma metabolites measured by LC-tandem MS. Results: Higher baseline kynurenine:tryptophan ratio (OR for 1 SD: 1.20; 95% CI: 1.01, 1.43) and higher levels of kynurenic acid (OR: 1.19; 95% CI: 1.01. 1.40) were associated with HF. Quinolinic acid was associated with AF (OR: 1.15: 95% CI: 1.01, 1.32) and HF (OR: 1.25: 95% CI: 1.04. 1.49). The MedDiet intervention modified the positive associations of kynurenine (P-interaction = 0.006), kynurenic acid (P-interaction = 0.008), and quinolinic acid (P-interection = 0.033) with HF and the association between kynurenic acid and AF (P-interection = 0.02). Conclusions: We found that tryptophan-kynurenine pathway metabolites were prospectively associated with higher HF risk and to a lesser extent with AF risk. Moreover, an effect modification by MedDiet was observed for the association between plasma baseline kynurenine-related metabolites and the risk of HF, showing that the positive association of increased levels of these metabolites and HF was restricted to the control group.

引用

页码：1646 / 1654

页数：9

共 5 条

[1] Plasma acylcarnitine, risk for heart failure or atrial fibrillation, and effects of the Mediterranean diet or obesity
Del Franco, Annamaria
Morfino, Paolo
Aimo, Alberto
REVISTA ESPANOLA DE CARDIOLOGIA, 2022, 75 (08): : 621 - 622
[2] Potential role of the geriatric nutritional risk index as a novel risk factor for the development of non-valvular atrial fibrillation in patients with heart failure
Kaplan, M.
Vuruskan, E.
Altunbas, G.
Yavuz, F.
Kaplan, G., I
Duzen, I., V
Alic, E.
Savcilioglu, M. D.
Annac, S.
Bursa, N.
Sucu, N. M.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2021, 122 (09): : 636 - 642
[3] Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet
Pastori, Daniele
Carnevale, Roberto
Nocella, Cristina
Novo, Marta
Santulli, Maria
Cammisotto, Vittoria
Menichelli, Danilo
Pignatelli, Pasquale
Violi, Francesco
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (06):
[4] ASYMPTOMATIC HYPERURICEMIA AS A POTENTIAL METABOLIC RISK FACTOR FOR CORONARY ARTERY CALCIFICATION IN PATIENTS WITH ATRIAL FIBRILLATION OR HEART FAILURE
Pasheva, Milena
Yotov, Yoto
Nikolova, Miglena
Gerova, Daniela
Angelov, Atanas
Galunska, Bistra
JOURNAL OF IMAB, 2021, 27 (01): : 3634 - 3642
[5] Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: A Bidirectional Mendelian Randomization Study Using Genome-wide Association Data
Mei, Yibin
Ye, Fang
Yin, Xiaofen
Wu, Xianjun
ANATOLIAN JOURNAL OF CARDIOLOGY, 2024, 28 (08):

← 1 →