World Health Organization Group I Pulmonary Hypertension Epidemiology and Pathophysiology

被引：117

作者：

Prins, Kurt W. ^{[1
]}

Thenappan, Thenappan ^{[2
]}

机构：

[1] Univ Minnesota, Sch Med, Div Cardiovasc, 420 Delaware St Southeast, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sect Adv Heart Failure & Pulm Hypertens, Div Cardiovasc, Sch Med, 420 Delaware St Southeast, Minneapolis, MN 55455 USA

来源：

CARDIOLOGY CLINICS | 2016年 / 34卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Pulmonary arterial hypertension; Epidemiology; Right ventricle; Pulmonary vasculature; Pathophysiology; RIGHT-VENTRICULAR HYPERTROPHY; HEREDITARY HEMORRHAGIC TELANGIECTASIA; SERINE ELASTASE INHIBITOR; CAPILLARY WEDGE PRESSURE; MYOSIN HEAVY-CHAIN; ARTERIAL-HYPERTENSION; CONTRACTILE DYSFUNCTION; ELASTOLYTIC ACTIVITY; CASTLEMANS-DISEASE; CHINESE PATIENTS;

D O I：

10.1016/j.ccl.2016.04.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary arterial hypertension (PAH) is a debilitating disease characterized by pathologic remodeling of the resistance pulmonary arteries, ultimately leading to right ventricular (RV) failure and death. In this article we discuss the definition of PAH, the initial epidemiology based on the National Institutes of Health Registry, and the updated epidemiology gleaned from contemporary registries, pathogenesis of pulmonary vascular dysfunction and proliferation, and RV failure in PAH.

引用

页码：363 / +

页数：13

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