Efficient Synthesis of 2,2-Diaryl-1,1-difluoroethenes via Consecutive Cross-Coupling Reactions of 2,2-Difluoro-1-tributylstannylethenyl p-Toluenesulfonate

被引：44

作者：

Han, Seung Yeon ^{[1
]}

Jeong, In Howa ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem & Med Chem, Wonju 220710, South Korea

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

POTENTIAL INHIBITORS; CARBONYL-COMPOUNDS; CYCLIZATION; KETONES; ALDEHYDES; ACIDS;

D O I：

10.1021/ol1024037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,2-Difluoro-1-tributylstannylethenyl p-toluenesulfonate (2) was reacted with aryl iodides in the presence of 10 mol % of Pd(PPh3)(4) and 10 mol % of Cul in DMF at 80 degrees C for 10-20 h to give the cross-coupled products 3 in 35-97% yields. Further coupling reaction of 3 with arylstannanes in the presence of 5 mol % of Pd(PFh(3))(4) and 3 equiv of LiBr in DMF at 100 degrees C for 2-24 h afforded the desired products 5 in 25-78% yields.

引用

页码：5518 / 5521

页数：4

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