Autonomic nervous system activity changes in patients with hypertension and overweight: role and therapeutic implications

被引:76
作者
Valensi, Paul [1 ]
机构
[1] Paris Nord Univ, Jean Verdier Hosp, AP HP, Unit Endocrinol Diabetol & Nutr,CINFO,CRNH IdF, Ave 14 Juillet, F-93140 Bondy, France
关键词
Autonomic nervous system; Hypertension; Obesity; Type; 2; diabetes; Selective imidazoline receptor agonists; GLUCAGON-LIKE PEPTIDE-1; HEART-RATE-VARIABILITY; ARTERIAL-BLOOD-PRESSURE; SYMPATHETIC ACTIVATION; BAROREFLEX SENSITIVITY; VAGOSYMPATHETIC ACTIVITY; INSULIN SENSITIVITY; METABOLIC SYNDROME; ENERGY-METABOLISM; RENAL DENERVATION;
D O I
10.1186/s12933-021-01356-w
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The incidence and prevalence of hypertension is increasing worldwide, with approximately 1.13 billion of people currently affected by the disease, often in association with other diseases such as diabetes mellitus, chronic kidney disease, dyslipidemia/hypercholesterolemia, and obesity. The autonomic nervous system has been implicated in the pathophysiology of hypertension, and treatments targeting the sympathetic nervous system (SNS), a key component of the autonomic nervous system, have been developed; however, current recommendations provide little guidance on their use. This review discusses the etiology of hypertension, and more specifically the role of the SNS in the pathophysiology of hypertension and its associated disorders. In addition, the effects of current antihypertensive management strategies, including pharmacotherapies, on the SNS are examined, with a focus on imidazoline receptor agonists.
引用
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页数:12
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