Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids

被引：169

作者：

Dickson, Eamonn J. ^{[1
]}

Hille, Bertil ^{[2
]}

机构：

[1] Univ Calif Davis, Dept Physiol & Membrane Biol, Davis, CA 95616 USA

[2] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

BIOCHEMICAL JOURNAL | 2019年 / 476卷

关键词：

VOLTAGE-SENSING PHOSPHATASE; PLASMA-MEMBRANE; ENDOPLASMIC-RETICULUM; POTASSIUM CHANNELS; MUSCARINIC RECEPTOR; K+ CHANNEL; PHOSPHATIDYLINOSITOL 3,4-BISPHOSPHATE; QUANTITATIVE PROPERTIES; DEPENDENT REGULATION; STIMULATES SYNTHESIS;

D O I：

10.1042/BCJ20180022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.

引用

页码：1 / 23

页数：23

共 183 条

[1] PHARMACOLOGICAL INHIBITION OF THE M-CURRENT [J].

ADAMS, PR ;

BROWN, DA ;

CONSTANTI, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 332 (NOV) :223-262

[2] Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction [J].

Amarilio, R ;

Ramachandran, S ;

Sabanay, H ;

Lev, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (07) :5934-5944

[3] The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol [J].

Antonny, Bruno ;

Bigay, Joelle ;

Mesmin, Bruno .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87, 2018, 87 :809-837

[4] PHOSPHOINOSITIDES: TINY LIPIDS WITH GIANT IMPACT ON CELL REGULATION [J].

Balla, Tamas .

PHYSIOLOGICAL REVIEWS, 2013, 93 (03) :1019-1137

[5] The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane [J].

Baskin, Jeremy M. ;

Wu, Xudong ;

Christiano, Romain ;

Oh, Michael S. ;

Schauder, Curtis M. ;

Gazzerro, Elisabetta ;

Messa, Mirko ;

Baldassari, Simona ;

Assereto, Stefania ;

Biancheri, Roberta ;

Zara, Federico ;

Minetti, Carlo ;

Raimondi, Andrea ;

Simons, Mikael ;

Walther, Tobias C. ;

Reinisch, Karin M. ;

De Camilli, Pietro .

NATURE CELL BIOLOGY, 2016, 18 (01) :132-+

[6] Light-activated protein interaction with high spatial subcellular confinement [J].

Benedetti, Lorena ;

Barentine, Andrew E. S. ;

Messa, Mirko ;

Wheeler, Heather ;

Bewersdorf, Joerg ;

De Camilli, Pietro .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (10) :E2238-E2245

[7] Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease [J].

Bennett, Steffany A. L. ;

Valenzuela, Nicolas ;

Xu, Hongbin ;

Franko, Bettina ;

Fai, Stephen ;

Figeys, Daniel .

FRONTIERS IN PHYSIOLOGY, 2013, 4

[8] Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism [J].

Berman, Diego E. ;

Dall'Armi, Claudia ;

Voronov, Sergey V. ;

McIntire, Laura Beth J. ;

Zhang, Hong ;

Moore, Ann Z. ;

Staniszewski, Agniezka ;

Arancio, Ottavio ;

Kim, Tae-Wan ;

Di Paolo, Gilbert .

NATURE NEUROSCIENCE, 2008, 11 (05) :547-554

[9] A DIFFUSIBLE 2ND MESSENGER MEDIATES ONE OF THE PATHWAYS COUPLING RECEPTORS TO CALCIUM CHANNELS IN RAT SYMPATHETIC NEURONS [J].

BERNHEIM, L ;

BEECH, DJ ;

HILLE, B .

NEURON, 1991, 6 (06) :859-867

[10] THE INOSITOL TRISPHOSPHATE/CALCIUM SIGNALING PATHWAY IN HEALTH AND DISEASE [J].

Berridge, Michael J. .

PHYSIOLOGICAL REVIEWS, 2016, 96 (04) :1261-1296

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