The Effect of Leukocyte Concentration on Platelet-Rich Plasma Injections for Knee Osteoarthritis A Network Meta-Analysis
被引:31
作者:
Abbas, Aazad
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Univ Toronto, North York Gen Hosp, Toronto, ON, Canada
Univ Toronto, Temerty Fac Med, Toronto, ON, CanadaUniv Toronto, North York Gen Hosp, Toronto, ON, Canada
Abbas, Aazad
[1
,2
]
Du, Jin Tong
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机构:
Univ Toronto, North York Gen Hosp, Toronto, ON, Canada
Univ Toronto, Temerty Fac Med, Toronto, ON, CanadaUniv Toronto, North York Gen Hosp, Toronto, ON, Canada
Du, Jin Tong
[1
,2
]
Dhotar, Herman S.
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机构:
Univ Toronto, North York Gen Hosp, Toronto, ON, Canada
Univ Toronto, Temerty Fac Med, Toronto, ON, Canada
Univ Toronto, North York Gen Hosp, Dept Orthopaed Surg, N York, ON, Canada
Univ Toronto, Dept Surg, Toronto, ON, CanadaUniv Toronto, North York Gen Hosp, Toronto, ON, Canada
Dhotar, Herman S.
[1
,2
,3
,4
]
机构:
[1] Univ Toronto, North York Gen Hosp, Toronto, ON, Canada
[2] Univ Toronto, Temerty Fac Med, Toronto, ON, Canada
[3] Univ Toronto, North York Gen Hosp, Dept Orthopaed Surg, N York, ON, Canada
Background: It is hypothesized that leukocyte-poor (LP) platelet-rich plasma (PRP) is preferred over leukocyte-rich (LR) PRP for the treatment of knee osteoarthritis (OA). Methods: The MEDLINE, Embase, and Cochrane databases were reviewed for all English-language studies comparing LP-PRP or LR-PRP with relevant controls or each other. The follow-up periods were 6 months and 12 months. The primary outcome measure was the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score between baseline and follow-up. The secondary outcome measures were changes in the WOMAC pain subscale, visual analog scale (VAS) for pain, and International Knee Documentation Committee (IKDC) subjective score between baseline and follow-up, and the incidence of local adverse reactions. Treatment outcomes were analyzed using the mean difference between treatments for continuous outcomes and the odds ratio for binary outcomes, with 95% credibility intervals. Treatment modalities were ranked using the surface under the cumulative ranking (SUCRA) probabilities. Risk of bias was assessed using the relevant Cochrane tools, RoB 2 (version 2 of the Cochrane risk-of-bias tools) for randomized controlled trials (RCTs) and ROBINS-I (Risk of Bias in Non-Randomized Studies - of Interventions) for prospective comparative studies (PCSs). Results: This network meta-analysis included 23 studies: 20 RCTs and 3 PCSs, with a total of 2,260 patients and a mean follow-up period of 9.9 months. The overall risk-of-bias assessment of the RCTs revealed that 9 studies had low risk, 7 had some concerns, and 4 had high risk. The overall risk-of-bias assessment of the PCSs revealed that 1 study had low risk and 2 had moderate risk. We found no significant (p < 0.05) difference in all outcome measures and local adverse reactions between LP-PRP and LR-PRP. SUCRA rankings revealed that, for all outcome measures, LP-PRP is preferred to LR-PRP across follow-up periods. Conclusions: Leukocyte concentration of PRP does not play a significant role in patient-reported outcome measures for knee OA. LP-PRP is preferred to LR-PRP according to SUCRA rankings, but this preference may not be important in clinical practice.
机构:
Mashhad Univ Med Sci, Phys Med & Rehabil Dept, Mashhad, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
Hassanabadi, Hossein
;
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Fathi, Mohammad
;
Ghorbani, Elham
论文数: 0引用数: 0
h-index: 0
机构:
Shahid Beheshti Univ Med Sci, Phys Med & Rehabil Dept, Tehran, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
Ghorbani, Elham
;
Babaee, Marzieh
论文数: 0引用数: 0
h-index: 0
机构:
Shahid Beheshti Univ Med Sci, Phys Med & Rehabil Dept, Tehran, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
Babaee, Marzieh
;
Azma, Kamran
论文数: 0引用数: 0
h-index: 0
机构:
AJA Univ Med Sci, Phys Med & Rehabil Dept, Tehran, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Riboh, Jonathan C.
;
Saltzman, Bryan M.
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Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Saltzman, Bryan M.
;
Yanke, Adam B.
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h-index: 0
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Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Yanke, Adam B.
;
Fortier, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Cornell Sch Vet Med, Ithaca, NY USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Fortier, Lisa
;
Cole, Brian J.
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h-index: 0
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Saltzman, Bryan M.
;
Frank, Rachel M.
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Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Frank, Rachel M.
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Davey, Annabelle
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Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Davey, Annabelle
;
Cotter, Eric J.
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Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Cotter, Eric J.
;
Redondo, Michael L.
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Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Redondo, Michael L.
;
Naveen, Neal
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机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Naveen, Neal
;
Wang, Kevin C.
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Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Wang, Kevin C.
;
Cole, Brian J.
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机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
机构:
Mashhad Univ Med Sci, Phys Med & Rehabil Dept, Mashhad, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
Hassanabadi, Hossein
;
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机构:
Fathi, Mohammad
;
Ghorbani, Elham
论文数: 0引用数: 0
h-index: 0
机构:
Shahid Beheshti Univ Med Sci, Phys Med & Rehabil Dept, Tehran, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
Ghorbani, Elham
;
Babaee, Marzieh
论文数: 0引用数: 0
h-index: 0
机构:
Shahid Beheshti Univ Med Sci, Phys Med & Rehabil Dept, Tehran, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
Babaee, Marzieh
;
Azma, Kamran
论文数: 0引用数: 0
h-index: 0
机构:
AJA Univ Med Sci, Phys Med & Rehabil Dept, Tehran, IranShahid Beheshti Univ Med Sci, Shahid Modarres Hosp, Clin Dev Ctr, Phys Med & Rehabil Dept, Tehran, Iran
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Riboh, Jonathan C.
;
Saltzman, Bryan M.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Saltzman, Bryan M.
;
Yanke, Adam B.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Yanke, Adam B.
;
Fortier, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Cornell Sch Vet Med, Ithaca, NY USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
Fortier, Lisa
;
Cole, Brian J.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Div Sports Med, 1611 W Harrison St, Chicago, IL 60612 USA
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Saltzman, Bryan M.
;
Frank, Rachel M.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Frank, Rachel M.
;
Davey, Annabelle
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h-index: 0
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Davey, Annabelle
;
Cotter, Eric J.
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h-index: 0
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Cotter, Eric J.
;
Redondo, Michael L.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Redondo, Michael L.
;
Naveen, Neal
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Naveen, Neal
;
Wang, Kevin C.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA
Wang, Kevin C.
;
Cole, Brian J.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USARush Univ, Med Ctr, Orthopaed Surg, 1611 W Harrison St, Chicago, IL 60612 USA