The context preexposure facilitation effect in mice: A dose-response analysis of pretraining scopolamine administration

被引:15
作者
Brown, Kevin L. [1 ]
Kennard, John A. [1 ]
Sherer, Daniel J. [1 ]
Comalli, David M. [1 ]
Woodruff-Pak, Diana S. [1 ]
机构
[1] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA
关键词
CPFE; Context; Fear; Scopolamine; Mouse; SHOCK FREEZING DEFICIT; HIPPOCAMPAL-FORMATION; DORSAL HIPPOCAMPUS; CONJUNCTIVE REPRESENTATIONS; RETROGRADE-AMNESIA; FEAR; MEMORY; RATS; LESIONS; AMYGDALA;
D O I
10.1016/j.bbr.2011.07.044
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The context preexposure facilitation effect (CPFE) is an elaboration of contextual fear conditioning and refers to enhanced contextual conditioning resulting from preexposure to the context prior to a separate, brief context-shock episode. A version of the CPFE developed by Rudy and colleagues in rats has demonstrated greater sensitivity to pre-training hippocampal insult relative to standard contextual fear conditioning preparations. Our aim was to adapt the Rudy CPFE procedures to mice. In Experiment 1 we compared performance of young adult male C57BL6/J mice on two versions of the CPFE. One version - not previously used in mice - adapted methods established by Rudy and colleagues, and the other CPFE task replicated procedures previously established in this mouse strain by Gould and colleagues. In Experiment 2 we compared the effects of pre-training intraperitoneal administration of moderate levels of scopolamine or methylscopolamine on contextual conditioning between mice trained using the Rudy CPFE method and a separate group trained using standard contextual fear procedures. Scopolamine is a muscarinic cholinergic receptor antagonist that impairs hippocampal function. Robust freezing to the conditioning context was observed in mice trained using the Rudy CPFE method (Experiment 1), and greater scopolamine-induced impairments in contextual freezing were observed using this CPFE method relative to mice trained using standard contextual fear procedures (Experiment 2). These findings support use of the Rudy CPFE task as a behavioral assay for hippocampal function in mice. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:290 / 296
页数:7
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