Investigation on the relationship between the physicochemical properties of particles composed of a novel lipid A analog, E5531, and its pharmacokinetics

被引：0

作者：

Asai, Y ^{[1
]}

机构：

[1] Eisai & Co Ltd, Formulat Res Lab, Gifu 5016195, Japan

来源：

ADVANCED POWDER TECHNOLOGY | 2005年 / 16卷 / 04期

关键词：

lipid A; calcium ion; particle size; membrane fluidity; pharmacokinetics;

D O I：

10.1163/1568552054194177

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

To obtain information on the effects of a divalent cation (Ca2+) on the membrane properties of the lipid A analog, E5531, the particle size, zeta potential, membrane fluidity and pharmacokinctices was investigated in rats after the addition of calcium ion. Within a molar ratio for [Ca2+]/[E5531] <= 3, the presence of Ca2+ increased the zeta potentials of the E5531 membrane, but had no effect on particle size. Ca2+ decreased membrane fluidity and the pharmacokinetics in rats. These effects of Ca2+ on the membrane properties of E5531 particles could be eliminated by the addition of EDTA.

引用

页码：413 / 418

页数：6