Synthesis and characterization of novel biodegradable copolymers of 5-benzyloxy-1,3-dioxan-2-one and glycolide

被引：18

作者：

Cheng, SX ^{[1
]}

Miao, ZM ^{[1
]}

Wang, LS ^{[1
]}

Zhuo, RX ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2003年 / 24卷 / 18期

关键词：

biodegradable; copolymerization; polycarbonates; polyesters;

D O I：

10.1002/marc.200300085

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A series of novel biodegradable random copolymers of 5-benzyloxy-1,3-dioxan-2-one (5-benzyloxy-trimethylene carbonate, BTMC) and glycolide were synthesized by ring-<LF>opening polymerization. The copolymers were characterized by nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC). The incorporation of BTMC units into the copolymer chains results in good solubility of the polymers in common solvents. The in vitro degradation rate can be tailored by adjusting the composition of the copolymers.

引用

页码：1066 / 1069

页数：4

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